HitPredict

Interactor 1: EPHB2 (P29323)
Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2]
Gene: EPHB2

Interactor 2: PTN13 (Q12923)
Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1)
Gene: PTPN13

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~fn3, FERM_M~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~Y_phosphatase, PDZ~SAM_1, SAM_1~Y_phosphatase
Common GO terms	GO:0001933 - negative regulation of protein phosphorylation GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1055 Hs			1 2485
+	Hs
		1020163 EPHA7_HUMAN (6-982): 0: 1154: 57.46		PTN13_HUMAN (1-2485): 0: 1895: 100.00
+	Hs
		665393 EPHA3_HUMAN (16-980): 0: 1152: 56.37		PTN13_HUMAN (1-2485): 0: 1895: 100.00
+	Hs
		872638 EPHA4_HUMAN (6-982): 0: 1152: 58.33		PTN13_HUMAN (1-2485): 0: 1895: 100.00
+	Hs
		872431 EPHA5_HUMAN (6-984): 0: 1148: 56.69		PTN13_HUMAN (1-2485): 0: 1895: 100.00
+	Hs
		665228 EPHA2_HUMAN (18-980): 0: 1041: 47.98		PTN13_HUMAN (1-2485): 0: 1895: 100.00
+	Hs
		600564 EPHA1_HUMAN (12-976): 0: 961: 41.21		PTN13_HUMAN (1-2485): 0: 1895: 100.00
+	Hs
		665554 EPHB2_HUMAN (20-1055): 0: 1304: 100.00		MERL_HUMAN (558-1049): 1.41e-117: 388: 23.65
+	Hs
		665555 EPHB2_HUMAN (20-1055): 0: 1304: 100.00		RADI_HUMAN (574-969): 6.68e-116: 383: 26.94
+	Hs
		985961 EPHA7_HUMAN (6-982): 0: 1154: 57.46		PTN11_HUMAN (2083-2480): 4.2e-117: 387: 31.47
+	Hs
		872635 EPHA4_HUMAN (6-982): 0: 1152: 58.33		PTN11_HUMAN (2083-2480): 4.2e-117: 387: 31.47
+	Hs
		872429 EPHA5_HUMAN (6-984): 0: 1148: 56.69		PTN11_HUMAN (2083-2480): 4.2e-117: 387: 31.47
+	Hs
		719689 EPHA5_HUMAN (6-984): 0: 1148: 56.69		RADI_HUMAN (574-969): 6.68e-116: 383: 26.94
+	Hs
		665158 EPHA2_HUMAN (18-980): 0: 1041: 47.98		MERL_HUMAN (558-1049): 1.41e-117: 388: 23.65
+	Hs
		665220 EPHA2_HUMAN (18-980): 0: 1041: 47.98		PTN11_HUMAN (2083-2480): 4.2e-117: 387: 31.47
+	Hs
		616944 EPHA8_HUMAN (20-982): 0: 1066: 50.71		PTPRD_HUMAN (2189-2468): 1.65e-92: 337: 30.72
+	Hs
		600558 EPHA1_HUMAN (12-976): 0: 961: 41.21		PTN11_HUMAN (2083-2480): 4.2e-117: 387: 31.47
+	Hs
		573629 EPHA5_HUMAN (6-984): 0: 1148: 56.69		PTN1_HUMAN (2229-2465): 2.56e-45: 172: 37.40
+	Hs
		573583 EPHA8_HUMAN (20-982): 0: 1066: 50.71		PTN1_HUMAN (2229-2465): 2.56e-45: 172: 37.40
+	Hs
		872669 EPHA4_HUMAN (6-982): 0: 1152: 58.33		MAGI2_HUMAN (873-1270): 1.19e-11: 72.9: 16.50
+	Hs
		411278 INSR_HUMAN (277-941): 5.94e-150: 484: 24.02		PTPRC_HUMAN (2155-2465): 8.58e-71: 265: 24.78