HitPredict

Interactor 1: EPHB2 (P29323)
Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2]
Gene: EPHB2

Interactor 2: ABI1 (Q8IZP0)
Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1)
Gene: ABI1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1055 Hs			1 508
+	Hs
		665608 EPHB2_HUMAN (20-1055): 0: 1304: 100.00		ITSN1_HUMAN (399-504): 1.82e-09: 62.5: 20.35
+	Hs
		674424 UFO_HUMAN (266-950): 2.71e-152: 477: 23.12		SRC8_HUMAN (291-502): 1.23e-34: 138: 20.72
+	Hs
		433413 YES_HUMAN (572-881): 5.77e-65: 231: 42.95		ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00
+	Hs
		442853 HCK_HUMAN (575-881): 7.23e-65: 230: 40.91		ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00
+	Hs
		789126 FRK_HUMAN (591-873): 3.27e-64: 228: 41.90		ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00
+	Rn
		544889 INSR_RAT (280-937): 2.81e-145: 471: 24.56		Q68FX4_RAT (266-503): 1.98e-30: 125: 21.07
+	Hs
		601605 FGFR2_HUMAN (392-932): 6.72e-145: 455: 22.69		ITSN2_HUMAN (44-508): 6.18e-18: 89.8: 11.98
+	Hs
		435682 IGF1R_HUMAN (347-885): 2.31e-146: 474: 27.31		SH3R1_HUMAN (244-503): 3.15e-09: 61.6: 17.28
+	Hs
		433350 YES_HUMAN (572-881): 5.77e-65: 231: 42.95		SRC8_HUMAN (291-502): 1.23e-34: 138: 20.72
+	Hs
		442894 HCK_HUMAN (575-881): 7.23e-65: 230: 40.91		ASAP1_HUMAN (107-505): 8.23e-33: 135: 16.83
+	Mm
		639446 LYN_MOUSE (578-881): 1.82e-64: 229: 40.91		SRC8_MOUSE (291-502): 1.17e-33: 136: 20.64
+	Hs
		433354 YES_HUMAN (572-881): 5.77e-65: 231: 42.95		LASP1_HUMAN (285-503): 9.91e-33: 127: 19.28
+	Mm
		411921 LCK_MOUSE (579-881): 1.41e-65: 232: 41.78		HCLS1_MOUSE (266-503): 2.48e-29: 122: 20.07
+	Mm
		639438 LYN_MOUSE (578-881): 1.82e-64: 229: 40.91		HCLS1_MOUSE (266-503): 2.48e-29: 122: 20.07
+	Mm
		639449 LYN_MOUSE (578-881): 1.82e-64: 229: 40.91		DBNL_MOUSE (274-503): 6.55e-16: 81.9: 22.88
+	Hs
		442898 HCK_HUMAN (575-881): 7.23e-65: 230: 40.91		CD2AP_HUMAN (451-508): 2.26e-14: 77.9: 40.68