HitPredict

Interactor 1: EPHB2 (P29323)
Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2]
Gene: EPHB2

Interactor 2: LNX1 (Q8TBB1)
E3 ubiquitin-protein ligase LNX (EC 2.3.2.27) (Ligand of Numb-protein X 1) (Numb-binding protein 1) (PDZ domain-containing RING finger protein 2) (RING-type E3 ubiquitin transferase LNX)
Gene: LNX1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	31772302
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~fn3, PDZ~SAM_1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1055 Hs			1 728
+	Hs
		1072558 EPHA7_HUMAN (6-982): 0: 1154: 57.46		LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00
+	Hs
		872678 EPHA4_HUMAN (6-982): 0: 1152: 58.33		LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00
+	Hs
		872410 EPHB3_HUMAN (17-985): 0: 1142: 70.58		LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00
+	Hs
		1072546 EPHA7_HUMAN (6-982): 0: 1154: 57.46		LNX2_HUMAN (3-728): 5.7e-116: 366: 45.21
+	Hs
		665589 EPHB2_HUMAN (20-1055): 0: 1304: 100.00		PTN13_HUMAN (455-725): 4.02e-23: 107: 15.44
+	Hs
		665600 EPHB2_HUMAN (20-1055): 0: 1304: 100.00		SCRIB_HUMAN (265-624): 2.64e-15: 82.4: 13.52
+	Mm
		872623 EPHB2_MOUSE (1-985): 0: 1254: 99.49		GRIP1_MOUSE (507-720): 2.07e-12: 72.8: 28.84
+	Hs
		1072560 EPHA7_HUMAN (6-982): 0: 1154: 57.46		PARD3_HUMAN (247-554): 1.39e-32: 137: 20.96
+	Hs
		665414 EPHA3_HUMAN (16-980): 0: 1152: 56.37		PARD3_HUMAN (247-554): 1.39e-32: 137: 20.96
+	Hs
		872679 EPHA4_HUMAN (6-982): 0: 1152: 58.33		PARD3_HUMAN (247-554): 1.39e-32: 137: 20.96
+	Hs
		872464 EPHA5_HUMAN (6-984): 0: 1148: 56.69		PARD3_HUMAN (247-554): 1.39e-32: 137: 20.96
+	Hs
		1021499 EPHA7_HUMAN (6-982): 0: 1154: 57.46		DLG1_HUMAN (354-728): 3.16e-29: 126: 16.15
+	Hs
		872639 EPHA4_HUMAN (6-982): 0: 1152: 58.33		DLG1_HUMAN (354-728): 3.16e-29: 126: 16.15
+	Hs
		872433 EPHA5_HUMAN (6-984): 0: 1148: 56.69		DLG1_HUMAN (354-728): 3.16e-29: 126: 16.15
+	Hs
		1020163 EPHA7_HUMAN (6-982): 0: 1154: 57.46		PTN13_HUMAN (455-725): 4.02e-23: 107: 15.44
+	Hs
		665393 EPHA3_HUMAN (16-980): 0: 1152: 56.37		PTN13_HUMAN (455-725): 4.02e-23: 107: 15.44
+	Hs
		872638 EPHA4_HUMAN (6-982): 0: 1152: 58.33		PTN13_HUMAN (455-725): 4.02e-23: 107: 15.44
+	Hs
		872431 EPHA5_HUMAN (6-984): 0: 1148: 56.69		PTN13_HUMAN (455-725): 4.02e-23: 107: 15.44
+	Hs
		872669 EPHA4_HUMAN (6-982): 0: 1152: 58.33		MAGI2_HUMAN (151-509): 8.26e-19: 93.6: 11.36
+	Hs
		1049958 EPHA7_HUMAN (6-982): 0: 1154: 57.46		SCRIB_HUMAN (265-624): 2.64e-15: 82.4: 13.52