HitPredict

Interactor 1: EPHB2 (P29323)
Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2]
Gene: EPHB2

Interactor 2: LIN7C (Q9NUP9)
Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3)
Gene: LIN7C

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~fn3, PDZ~SAM_1
Common GO terms	GO:0005886 - plasma membrane GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1055 Hs			1 197
+	Hs
		665633 EPHB2_HUMAN (20-1055): 0: 1304: 100.00		LNX1_HUMAN (14-179): 1.21e-17: 82.1: 22.02
+	Hs
		665589 EPHB2_HUMAN (20-1055): 0: 1304: 100.00		PTN13_HUMAN (23-196): 2.66e-14: 72.5: 19.43
+	Hs
		665663 EPHB2_HUMAN (20-1055): 0: 1304: 100.00		GOPC_HUMAN (92-173): 2.58e-13: 69.3: 46.34
+	Hs
		665614 EPHB2_HUMAN (20-1055): 0: 1304: 100.00		PDZ11_HUMAN (91-175): 4.41e-13: 65.5: 45.35
+	Hs
		1072612 EPHA7_HUMAN (6-982): 0: 1154: 57.46		LIN7C_HUMAN (1-197): 1.38e-57: 181: 100.00
+	Hs
		1072518 EPHA7_HUMAN (6-982): 0: 1154: 57.46		MPP7_HUMAN (31-188): 6.36e-31: 119: 25.95
+	Hs
		159214 EPHA7_HUMAN (6-982): 0: 1154: 57.46		CSKP_HUMAN (13-194): 1.3e-30: 119: 20.53
+	Hs
		159179 EPHA4_HUMAN (6-982): 0: 1152: 58.33		CSKP_HUMAN (13-194): 1.3e-30: 119: 20.53
+	Hs
		1021499 EPHA7_HUMAN (6-982): 0: 1154: 57.46		DLG1_HUMAN (50-178): 8.31e-23: 97.1: 30.60
+	Hs
		872639 EPHA4_HUMAN (6-982): 0: 1152: 58.33		DLG1_HUMAN (50-178): 8.31e-23: 97.1: 30.60
+	Hs
		1072558 EPHA7_HUMAN (6-982): 0: 1154: 57.46		LNX1_HUMAN (14-179): 1.21e-17: 82.1: 22.02
+	Hs
		872678 EPHA4_HUMAN (6-982): 0: 1152: 58.33		LNX1_HUMAN (14-179): 1.21e-17: 82.1: 22.02
+	Hs
		1020163 EPHA7_HUMAN (6-982): 0: 1154: 57.46		PTN13_HUMAN (23-196): 2.66e-14: 72.5: 19.43
+	Hs
		665393 EPHA3_HUMAN (16-980): 0: 1152: 56.37		PTN13_HUMAN (23-196): 2.66e-14: 72.5: 19.43
+	Hs
		872638 EPHA4_HUMAN (6-982): 0: 1152: 58.33		PTN13_HUMAN (23-196): 2.66e-14: 72.5: 19.43
+	Hs
		1072604 EPHA7_HUMAN (6-982): 0: 1154: 57.46		GOPC_HUMAN (92-173): 2.58e-13: 69.3: 46.34
+	Hs
		665433 EPHA3_HUMAN (16-980): 0: 1152: 56.37		GOPC_HUMAN (92-173): 2.58e-13: 69.3: 46.34
+	Hs
		872713 EPHA4_HUMAN (6-982): 0: 1152: 58.33		GOPC_HUMAN (92-173): 2.58e-13: 69.3: 46.34
+	Hs
		1072516 EPHA7_HUMAN (6-982): 0: 1154: 57.46		PDZ11_HUMAN (91-175): 4.41e-13: 65.5: 45.35
+	Hs
		665403 EPHA3_HUMAN (16-980): 0: 1152: 56.37		PDZ11_HUMAN (91-175): 4.41e-13: 65.5: 45.35