HitPredict

Interactor 1: EPHB2 (P29323)
Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2]
Gene: EPHB2

Interactor 2: TNIK (Q9UKE5)
TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1)
Gene: TNIK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~fn3, PK_Tyr_Ser-Thr~Pkinase, Pkinase~SAM_1
Common GO terms	GO:0005524 - ATP binding GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1055 Hs			1 1360
+	Hs
		1072625 EPHA7_HUMAN (6-982): 0: 1154: 57.46		TNIK_HUMAN (1-1360): 0: 1235: 100.00
+	Hs
		872502 EPHA5_HUMAN (6-984): 0: 1148: 56.69		TNIK_HUMAN (1-1360): 0: 1235: 100.00
+	Hs
		324742 EPHB2_HUMAN (20-1055): 0: 1304: 100.00		M4K4_HUMAN (1-1360): 0: 970: 59.11
+	Hs
		1072547 EPHA7_HUMAN (6-982): 0: 1154: 57.46		MINK1_HUMAN (1-1360): 0: 1051: 60.43
+	Hs
		872460 EPHA5_HUMAN (6-984): 0: 1148: 56.69		MINK1_HUMAN (1-1360): 0: 1051: 60.43
+	Hs
		324809 EPHA7_HUMAN (6-982): 0: 1154: 57.46		M4K4_HUMAN (1-1360): 0: 970: 59.11
+	Hs
		324762 EPHA4_HUMAN (6-982): 0: 1152: 58.33		M4K4_HUMAN (1-1360): 0: 970: 59.11
+	Hs
		324761 EPHA5_HUMAN (6-984): 0: 1148: 56.69		M4K4_HUMAN (1-1360): 0: 970: 59.11
+	Hs
		324738 EPHA1_HUMAN (12-976): 0: 961: 41.21		M4K4_HUMAN (1-1360): 0: 970: 59.11
+	Hs
		647831 EPHB2_HUMAN (20-1055): 0: 1304: 100.00		MARK3_HUMAN (3-675): 1.72e-124: 406: 16.37
+	Hs
		665243 EPHA2_HUMAN (18-980): 0: 1041: 47.98		KS6A2_HUMAN (10-709): 1.39e-140: 449: 18.52
+	Hs
		324720 IGF1R_HUMAN (347-885): 2.31e-146: 474: 27.31		M4K4_HUMAN (1-1360): 0: 970: 59.11
+	Hs
		1072635 EPHA7_HUMAN (6-982): 0: 1154: 57.46		M4K5_HUMAN (19-373): 7.89e-73: 263: 40.38
+	Hs
		872510 EPHA5_HUMAN (6-984): 0: 1148: 56.69		M4K5_HUMAN (19-373): 7.89e-73: 263: 40.38
+	Hs
		600512 EPHA1_HUMAN (12-976): 0: 961: 41.21		MARK3_HUMAN (3-675): 1.72e-124: 406: 16.37
+	Hs
		601516 FGFR2_HUMAN (392-932): 6.72e-145: 455: 22.69		KS6A2_HUMAN (10-709): 1.39e-140: 449: 18.52
+	Hs
		601482 FGFR2_HUMAN (392-932): 6.72e-145: 455: 22.69		KS6A3_HUMAN (10-709): 1.25e-135: 435: 16.74
+	Hs
		601517 FGFR2_HUMAN (392-932): 6.72e-145: 455: 22.69		KS6A1_HUMAN (2-350): 9.65e-97: 329: 22.63
+	Hs
		433360 YES_HUMAN (572-881): 5.77e-65: 231: 42.95		KS6A2_HUMAN (10-709): 1.39e-140: 449: 18.52
+	Hs
		433470 YES_HUMAN (572-881): 5.77e-65: 231: 42.95		SIK2_HUMAN (15-915): 3.97e-124: 410: 14.70