HitPredict

Interactor 1: EPHB2 (P29323)
Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2]
Gene: EPHB2

Interactor 2: NISCH (Q9Y2I1)
Nischarin (Imidazoline receptor 1) (I-1) (IR1) (Imidazoline receptor antisera-selected protein) (hIRAS) (Imidazoline-1 receptor) (I1R) (Imidazoline-1 receptor candidate protein) (I-1 receptor candidate protein) (I1R candidate protein)
Gene: NISCH

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1055 Hs			1 1504
+	Hs
		1072633 EPHA7_HUMAN (6-982): 0: 1154: 57.46		NISCH_HUMAN (1-1504): 0: 1812: 100.00
+	Hs
		665440 EPHA3_HUMAN (16-980): 0: 1152: 56.37		NISCH_HUMAN (1-1504): 0: 1812: 100.00
+	Hs
		872733 EPHA4_HUMAN (6-982): 0: 1152: 58.33		NISCH_HUMAN (1-1504): 0: 1812: 100.00
+	Hs
		872509 EPHA5_HUMAN (6-984): 0: 1148: 56.69		NISCH_HUMAN (1-1504): 0: 1812: 100.00
+	Hs
		665544 EPHA8_HUMAN (20-982): 0: 1066: 50.71		NISCH_HUMAN (1-1504): 0: 1812: 100.00
+	Hs
		665370 EPHA2_HUMAN (18-980): 0: 1041: 47.98		NISCH_HUMAN (1-1504): 0: 1812: 100.00
+	Hs
		665600 EPHB2_HUMAN (20-1055): 0: 1304: 100.00		SCRIB_HUMAN (209-577): 1.3e-17: 91.7: 18.01
+	Hs
		665407 EPHA3_HUMAN (16-980): 0: 1152: 56.37		LRC49_HUMAN (190-453): 3.87e-30: 130: 20.60
+	Hs
		1049958 EPHA7_HUMAN (6-982): 0: 1154: 57.46		SCRIB_HUMAN (209-577): 1.3e-17: 91.7: 18.01
+	Hs
		665495 EPHA8_HUMAN (20-982): 0: 1066: 50.71		LRC49_HUMAN (190-453): 3.87e-30: 130: 20.60
+	At
		83731 Y5182_ARATH (347-914): 2.83e-161: 500: 16.80		Q9XGZ2_ARATH (2-714): 1.79e-90: 319: 12.05
+	At
		83704 Y5182_ARATH (347-914): 2.83e-161: 500: 16.80		Y4361_ARATH (174-666): 4.68e-69: 256: 12.80
+	At
		84729 F4I065_ARATH (364-917): 2.07e-160: 498: 18.14		Y4361_ARATH (174-666): 4.68e-69: 256: 12.80
+	At
		95366 F4I065_ARATH (364-917): 2.07e-160: 498: 18.14		RGI4_ARATH (129-665): 1.3e-54: 211: 15.20
+	At
		83725 Y5182_ARATH (347-914): 2.83e-161: 500: 16.80		MIK1_ARATH (115-609): 7.79e-51: 198: 15.95
+	At
		83721 Y5182_ARATH (347-914): 2.83e-161: 500: 16.80		Y3804_ARATH (260-586): 2.14e-38: 158: 19.35
+	At
		85102 F4I065_ARATH (364-917): 2.07e-160: 498: 18.14		RGI2_ARATH (1-154): 1.95e-19: 97.4: 10.13
+	At
		83729 Y5182_ARATH (347-914): 2.83e-161: 500: 16.80		CLV1_ARATH (3-154): 2.61e-16: 87: 6.63
+	At
		83702 Y5182_ARATH (347-914): 2.83e-161: 500: 16.80		RGI3_ARATH (406-666): 4.94e-16: 86.3: 10.19
+	At
		83724 Y5182_ARATH (347-914): 2.83e-161: 500: 16.80		PXC2_ARATH (333-564): 1.22e-12: 75.1: 17.09