HitPredict

Interactor 1: PTN6 (P29350)
Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1)
Gene: PTPN6

Interactor 2: VGFR2 (P35968)
Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)
Gene: KDR

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.888

Property	Details
Experiments	12887919, 28065597, 28183800, 18377662
Identification Methods	affinity chromatography technology, two hybrid, ubiquitin reconstruction, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0005576 - extracellular region GO:0005634 - nucleus GO:0008284 - positive regulation of cell population proliferation GO:0018108 - peptidyl-tyrosine phosphorylation GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 1356
+	Hs
		729658 PTPRR_HUMAN (5-515): 1.13e-123: 381: 24.86		VGFR2_HUMAN (1-1356): 0: 1028: 100.00
+	Hs
		452363 PTN6_HUMAN (1-595): 0: 628: 100.00		PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45
+	Hs
		499236 PTN6_HUMAN (1-595): 0: 628: 100.00		KIT_HUMAN (15-545): 5.99e-49: 192: 17.46
+	Hs
		665883 PTN6_HUMAN (1-595): 0: 628: 100.00		PTK7_HUMAN (329-882): 3.37e-42: 170: 13.58
+	Hs
		601466 PTN6_HUMAN (1-595): 0: 628: 100.00		FGFR2_HUMAN (1-231): 3.47e-24: 112: 9.57
+	Hs
		607888 PTN6_HUMAN (1-595): 0: 628: 100.00		FGFR4_HUMAN (538-817): 2.68e-15: 83.5: 14.42
+	Hs
		452355 PTPRB_HUMAN (102-541): 2.73e-119: 391: 26.85		PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45
+	Hs
		452425 PTPRR_HUMAN (5-515): 1.13e-123: 381: 24.86		PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45
+	Hs
		452346 PTN1_HUMAN (230-591): 2.86e-126: 380: 29.86		PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45
+	Hs
		452411 PTPRS_HUMAN (108-516): 3.34e-114: 376: 27.93		PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45
+	Hs
		452405 PTPRJ_HUMAN (234-549): 8.15e-115: 373: 33.12		PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45
+	Hs
		499261 PTPRJ_HUMAN (234-549): 8.15e-115: 373: 33.12		KIT_HUMAN (15-545): 5.99e-49: 192: 17.46
+	Hs
		1031133 PTPRR_HUMAN (5-515): 1.13e-123: 381: 24.86		PTK7_HUMAN (329-882): 3.37e-42: 170: 13.58
+	Hs
		169163 PTN1_HUMAN (230-591): 2.86e-126: 380: 29.86		MUSK_HUMAN (1-213): 3.21e-30: 131: 12.83
+	Hs
		601515 PTPRR_HUMAN (5-515): 1.13e-123: 381: 24.86		FGFR2_HUMAN (1-231): 3.47e-24: 112: 9.57
+	Hs
		572587 PTPRB_HUMAN (102-541): 2.73e-119: 391: 26.85		VGFR1_HUMAN (1-131): 5.1e-20: 99.3: 13.38
+	Hs
		507839 PTN1_HUMAN (230-591): 2.86e-126: 380: 29.86		FGFR1_HUMAN (1-169): 8.34e-17: 88.1: 13.54
+	Hs
		607973 PTPRR_HUMAN (5-515): 1.13e-123: 381: 24.86		FGFR4_HUMAN (538-817): 2.68e-15: 83.5: 14.42
+	Hs
		507980 PTPRS_HUMAN (108-516): 3.34e-114: 376: 27.93		FGFR1_HUMAN (1-169): 8.34e-17: 88.1: 13.54
+	Hs
		573600 PTN1_HUMAN (230-591): 2.86e-126: 380: 29.86		VGFR3_HUMAN (1-123): 1.31e-13: 78.1: 14.93