HitPredict

Interactor 1: PTN6 (P29350)
Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1)
Gene: PTPN6

Interactor 2: KI2L3 (P43628)
Killer cell immunoglobulin-like receptor 2DL3 (CD158 antigen-like family member B2) (KIR-023GB) (Killer inhibitory receptor cl 2-3) (NKAT2a) (NKAT2b) (Natural killer-associated transcript 2) (NKAT-2) (p58 natural killer cell receptor clone CL-6) (p58 NK receptor CL-6) (p58.2 MHC class-I-specific NK receptor) (CD antigen CD158b2)
Gene: KIR2DL3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.687

Property	Details
Experiments	9148918, 8574854, 8648092, 8691154
Identification Methods	affinity chromatography technology, pull down, surface plasmon resonance, coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 341
+	Hs
		665819 PTN6_HUMAN (1-595): 0: 628: 100.00		KI2L1_HUMAN (1-340): 1.84e-126: 368: 90.59
+	Hs
		252776 PTN6_HUMAN (1-595): 0: 628: 100.00		LIRB3_HUMAN (1-296): 1.22e-68: 227: 27.67
+	Mm
		665991 PTN6_MOUSE (1-595): 0: 611: 94.45		LRB4A_MOUSE (1-336): 7.44e-72: 228: 27.43
+	Hs
		665821 PTN6_HUMAN (1-595): 0: 628: 100.00		KI3L1_HUMAN (1-251): 2.24e-63: 209: 38.19
+	Hs
		665916 PTN6_HUMAN (1-595): 0: 628: 100.00		LIRB2_HUMAN (17-341): 1.02e-45: 165: 30.56
+	Hs
		665804 PTN6_HUMAN (1-595): 0: 628: 100.00		FCG2B_HUMAN (8-317): 8.68e-43: 151: 16.15
+	Hs
		665902 PTN6_HUMAN (1-595): 0: 628: 100.00		LAIR1_HUMAN (1-144): 6.7e-38: 138: 25.83
+	Hs
		665921 PTN6_HUMAN (1-595): 0: 628: 100.00		LIRB4_HUMAN (17-337): 4.91e-30: 120: 24.22
+	Hs
		616953 PTPRD_HUMAN (126-516): 3.18e-114: 376: 29.41		KI2L1_HUMAN (1-340): 1.84e-126: 368: 90.59
+	Mm
		665982 PTN6_MOUSE (1-595): 0: 611: 94.45		LIRB3_MOUSE (21-258): 1.97e-33: 132: 25.93
+	Hs
		590601 PTN6_HUMAN (1-595): 0: 628: 100.00		CD22_HUMAN (11-246): 1.51e-14: 76.8: 16.67
+	Mm
		665995 PTN6_MOUSE (1-595): 0: 611: 94.45		LAIR1_MOUSE (1-183): 1.53e-18: 85.6: 16.42
+	Hs
		665922 PTN6_HUMAN (1-595): 0: 628: 100.00		LIRB1_HUMAN (278-337): 8.29e-10: 61.8: 25.00
+	Hs
		616999 PTPRD_HUMAN (126-516): 3.18e-114: 376: 29.41		LIRB4_HUMAN (17-337): 4.91e-30: 120: 24.22
+	Hs
		798184 PTN11_HUMAN (2-203): 1.25e-24: 110: 25.23		KI2L3_HUMAN (1-341): 4.64e-132: 381: 100.00
+	Hs
		798139 PTN11_HUMAN (2-203): 1.25e-24: 110: 25.23		KI2L1_HUMAN (1-340): 1.84e-126: 368: 90.59
+	Hs
		441175 PTPRC_HUMAN (118-575): 2.27e-82: 283: 20.20		CD22_HUMAN (11-246): 1.51e-14: 76.8: 16.67
+	Hs
		798232 PTN11_HUMAN (2-203): 1.25e-24: 110: 25.23		KI3L1_HUMAN (1-251): 2.24e-63: 209: 38.19
+	Hs
		685206 PTN11_HUMAN (2-203): 1.25e-24: 110: 25.23		FCG2B_HUMAN (8-317): 8.68e-43: 151: 16.15
+	Hs
		985972 PTN11_HUMAN (2-203): 1.25e-24: 110: 25.23		LAIR1_HUMAN (1-144): 6.7e-38: 138: 25.83