HitPredict

Interactor 1: PTN6 (P29350)
Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1)
Gene: PTPN6

Interactor 2: PTK7 (Q13308)
Inactive tyrosine-protein kinase 7 (Colon carcinoma kinase 4) (CCK-4) (Protein-tyrosine kinase 7) (Pseudo tyrosine kinase receptor 7) (Tyrosine-protein kinase-like 7)
Gene: PTK7

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	28065597
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0005911 - cell-cell junction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 1070
+	Hs
		384330 PTN6_HUMAN (1-595): 0: 628: 100.00		NTRK1_HUMAN (555-1061): 3.09e-57: 214: 30.31
+	Hs
		445827 PTN6_HUMAN (1-595): 0: 628: 100.00		ROS1_HUMAN (791-1061): 2.82e-53: 206: 39.07
+	Mm
		665993 PTN6_MOUSE (1-595): 0: 611: 94.45		ROS1_MOUSE (791-1061): 7.02e-53: 205: 38.71
+	Hs
		601466 PTN6_HUMAN (1-595): 0: 628: 100.00		FGFR2_HUMAN (297-603): 8.71e-43: 170: 18.52
+	Hs
		607888 PTN6_HUMAN (1-595): 0: 628: 100.00		FGFR4_HUMAN (2-127): 8.1e-14: 78.2: 17.73
+	Hs
		384278 PTPRB_HUMAN (102-541): 2.73e-119: 391: 26.85		NTRK1_HUMAN (555-1061): 3.09e-57: 214: 30.31
+	Hs
		384881 PTPRR_HUMAN (5-515): 1.13e-123: 381: 24.86		NTRK1_HUMAN (555-1061): 3.09e-57: 214: 30.31
+	Hs
		616937 PTPRB_HUMAN (102-541): 2.73e-119: 391: 26.85		ALK_HUMAN (695-1067): 1.21e-52: 204: 32.90
+	Hs
		384228 PTN1_HUMAN (230-591): 2.86e-126: 380: 29.86		NTRK1_HUMAN (555-1061): 3.09e-57: 214: 30.31
+	Hs
		384777 PTPRS_HUMAN (108-516): 3.34e-114: 376: 27.93		NTRK1_HUMAN (555-1061): 3.09e-57: 214: 30.31
+	Hs
		445820 PTN1_HUMAN (230-591): 2.86e-126: 380: 29.86		ROS1_HUMAN (791-1061): 2.82e-53: 206: 39.07
+	Hs
		573975 PTN1_HUMAN (230-591): 2.86e-126: 380: 29.86		ALK_HUMAN (695-1067): 1.21e-52: 204: 32.90
+	Hs
		1031133 PTPRR_HUMAN (5-515): 1.13e-123: 381: 24.86		PTK7_HUMAN (2-329): 4.66e-52: 201: 19.94
+	Hs
		601515 PTPRR_HUMAN (5-515): 1.13e-123: 381: 24.86		FGFR2_HUMAN (297-603): 8.71e-43: 170: 18.52
+	Hs
		572587 PTPRB_HUMAN (102-541): 2.73e-119: 391: 26.85		VGFR1_HUMAN (225-713): 1.05e-34: 146: 16.99
+	Hs
		507839 PTN1_HUMAN (230-591): 2.86e-126: 380: 29.86		FGFR1_HUMAN (2-231): 7.15e-34: 142: 12.41
+	Hs
		573718 PTN1_HUMAN (230-591): 2.86e-126: 380: 29.86		NTRK2_HUMAN (43-313): 2.12e-18: 92.8: 16.12
+	Hs
		573716 PTN1_HUMAN (230-591): 2.86e-126: 380: 29.86		NTRK3_HUMAN (40-228): 3.71e-16: 85.9: 19.10
+	Hs
		607973 PTPRR_HUMAN (5-515): 1.13e-123: 381: 24.86		FGFR4_HUMAN (2-127): 8.1e-14: 78.2: 17.73
+	Hs
		169163 PTN1_HUMAN (230-591): 2.86e-126: 380: 29.86		MUSK_HUMAN (130-422): 5.54e-12: 72: 21.93