HitPredict

Interactor 1: PTN6 (P29350)
Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1)
Gene: PTPN6

Interactor 2: LAIR1 (Q6GTX8)
Leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) (hLAIR1) (CD antigen CD305)
Gene: LAIR1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.50	0.686

Property	Details
Experiments	15703304, 10903717, 9285412, 10764762, 11160222, 10660620, 11171044, 11328818
Identification Methods	affinity chromatography technology, two hybrid, pull down, coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 287
+	Mm
		665995 PTN6_MOUSE (1-595): 0: 611: 94.45		LAIR1_MOUSE (16-287): 2.9e-74: 229: 40.22
+	Hs
		665921 PTN6_HUMAN (1-595): 0: 628: 100.00		LIRB4_HUMAN (1-246): 1.52e-56: 190: 25.59
+	Hs
		665820 PTN6_HUMAN (1-595): 0: 628: 100.00		KI2L3_HUMAN (1-162): 4.77e-38: 138: 21.82
+	Hs
		665821 PTN6_HUMAN (1-595): 0: 628: 100.00		KI3L1_HUMAN (1-154): 1.94e-35: 133: 21.66
+	Hs
		665819 PTN6_HUMAN (1-595): 0: 628: 100.00		KI2L1_HUMAN (1-162): 1.22e-32: 124: 20.61
+	Mm
		665991 PTN6_MOUSE (1-595): 0: 611: 94.45		LRB4A_MOUSE (21-286): 1.86e-31: 121: 18.22
+	Hs
		665916 PTN6_HUMAN (1-595): 0: 628: 100.00		LIRB2_HUMAN (28-150): 6.91e-23: 99: 24.00
+	Hs
		665922 PTN6_HUMAN (1-595): 0: 628: 100.00		LIRB1_HUMAN (28-150): 2.12e-22: 98.7: 23.20
+	Hs
		252776 PTN6_HUMAN (1-595): 0: 628: 100.00		LIRB3_HUMAN (28-156): 1.39e-20: 93.4: 22.90
+	Mm
		665982 PTN6_MOUSE (1-595): 0: 611: 94.45		LIRB3_MOUSE (23-150): 7.81e-17: 82.6: 19.23
+	Hs
		616999 PTPRD_HUMAN (126-516): 3.18e-114: 376: 29.41		LIRB4_HUMAN (1-246): 1.52e-56: 190: 25.59
+	Hs
		616953 PTPRD_HUMAN (126-516): 3.18e-114: 376: 29.41		KI2L1_HUMAN (1-162): 1.22e-32: 124: 20.61
+	Hs
		985972 PTN11_HUMAN (2-203): 1.25e-24: 110: 25.23		LAIR1_HUMAN (1-287): 5.63e-103: 303: 100.00
+	Hs
		798184 PTN11_HUMAN (2-203): 1.25e-24: 110: 25.23		KI2L3_HUMAN (1-162): 4.77e-38: 138: 21.82
+	Hs
		798232 PTN11_HUMAN (2-203): 1.25e-24: 110: 25.23		KI3L1_HUMAN (1-154): 1.94e-35: 133: 21.66
+	Hs
		986023 PTN11_HUMAN (2-203): 1.25e-24: 110: 25.23		KI2L4_HUMAN (1-162): 3.9e-35: 131: 24.85
+	Hs
		798139 PTN11_HUMAN (2-203): 1.25e-24: 110: 25.23		KI2L1_HUMAN (1-162): 1.22e-32: 124: 20.61
+	Mm
		719307 PTN11_MOUSE (2-203): 1.41e-24: 110: 25.23		LRB4A_MOUSE (21-286): 1.86e-31: 121: 18.22
+	Mm
		719293 PTN11_MOUSE (2-203): 1.41e-24: 110: 25.23		LIRB3_MOUSE (23-150): 7.81e-17: 82.6: 19.23
+	Mm
		719316 PTN11_MOUSE (2-203): 1.41e-24: 110: 25.23		Q8K4V6_MOUSE (21-155): 4.72e-16: 79.9: 20.71