HitPredict

Interactor 1: PTN6 (P29350)
Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1)
Gene: PTPN6

Interactor 2: LMTK2 (Q8IWU2)
Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2)
Gene: LMTK2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	28065597
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 1503
+	Hs
		665906 PTN6_HUMAN (1-595): 0: 628: 100.00		LMTK1_HUMAN (14-1500): 0: 702: 29.02
+	Hs
		665895 PTN6_HUMAN (1-595): 0: 628: 100.00		ERBB4_HUMAN (17-748): 3.15e-132: 444: 18.30
+	Hs
		601466 PTN6_HUMAN (1-595): 0: 628: 100.00		FGFR2_HUMAN (33-454): 4.84e-123: 406: 20.31
+	Hs
		337361 PTN6_HUMAN (1-595): 0: 628: 100.00		ABL1_HUMAN (84-931): 1.76e-117: 399: 18.90
+	Hs
		665889 PTN6_HUMAN (1-595): 0: 628: 100.00		FAK2_HUMAN (66-696): 3.04e-118: 398: 17.76
+	Hs
		433603 PTN6_HUMAN (1-595): 0: 628: 100.00		LYN_HUMAN (86-421): 2.69e-109: 358: 22.19
+	Mm
		639436 PTN6_MOUSE (1-595): 0: 611: 94.45		LYN_MOUSE (86-421): 1.05e-109: 359: 22.19
+	Hs
		337358 PTN4_HUMAN (78-519): 2.47e-122: 385: 27.61		ABL1_HUMAN (84-931): 1.76e-117: 399: 18.90
+	Hs
		384330 PTN6_HUMAN (1-595): 0: 628: 100.00		NTRK1_HUMAN (131-410): 1.29e-36: 152: 33.33
+	Hs
		411311 PTN6_HUMAN (1-595): 0: 628: 100.00		INSR_HUMAN (93-407): 2.85e-34: 145: 32.82
+	Hs
		435549 PTN6_HUMAN (1-595): 0: 628: 100.00		IGF1R_HUMAN (131-399): 1.23e-33: 144: 33.33
+	Hs
		445827 PTN6_HUMAN (1-595): 0: 628: 100.00		ROS1_HUMAN (122-443): 4.68e-32: 139: 31.56
+	Hs
		665883 PTN6_HUMAN (1-595): 0: 628: 100.00		PTK7_HUMAN (28-403): 9.63e-31: 134: 29.05
+	Hs
		665863 PTN6_HUMAN (1-595): 0: 628: 100.00		ROR1_HUMAN (112-404): 2.34e-29: 129: 28.57
+	Mm
		665993 PTN6_MOUSE (1-595): 0: 611: 94.45		ROS1_MOUSE (153-411): 8.35e-33: 141: 32.61
+	Hs
		384278 PTPRB_HUMAN (102-541): 2.73e-119: 391: 26.85		NTRK1_HUMAN (131-410): 1.29e-36: 152: 33.33
+	Hs
		411297 PTPRB_HUMAN (102-541): 2.73e-119: 391: 26.85		INSR_HUMAN (93-407): 2.85e-34: 145: 32.82
+	Hs
		384881 PTPRR_HUMAN (5-515): 1.13e-123: 381: 24.86		NTRK1_HUMAN (131-410): 1.29e-36: 152: 33.33
+	Hs
		411302 PTN3_HUMAN (118-523): 9.92e-122: 383: 27.70		INSR_HUMAN (93-407): 2.85e-34: 145: 32.82
+	Hs
		616906 PTPRB_HUMAN (102-541): 2.73e-119: 391: 26.85		TEC_HUMAN (123-410): 1.39e-31: 134: 30.61