HitPredict

Interactor 1: PTN6 (P29350)
Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1)
Gene: PTPN6

Interactor 2: LIRB2 (Q8N423)
Leukocyte immunoglobulin-like receptor subfamily B member 2 (LIR-2) (Leukocyte immunoglobulin-like receptor 2) (CD85 antigen-like family member D) (Immunoglobulin-like transcript 4) (ILT-4) (Monocyte/macrophage immunoglobulin-like receptor 10) (MIR-10) (CD antigen CD85d)
Gene: LILRB2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.576

Property	Details
Experiments	12163025, 18802077
Identification Methods	two hybrid, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0016020 - membrane GO:0019221 - cytokine-mediated signaling pathway GO:0042130 - negative regulation of T cell proliferation GO:0050839 - cell adhesion molecule binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 597
+	Hs
		665922 PTN6_HUMAN (1-595): 0: 628: 100.00		LIRB1_HUMAN (1-597): 1.37e-123: 380: 76.92
+	Hs
		252776 PTN6_HUMAN (1-595): 0: 628: 100.00		LIRB3_HUMAN (1-597): 2.64e-120: 371: 63.17
+	Hs
		665821 PTN6_HUMAN (1-595): 0: 628: 100.00		KI3L1_HUMAN (1-333): 1.59e-66: 225: 38.58
+	Hs
		665921 PTN6_HUMAN (1-595): 0: 628: 100.00		LIRB4_HUMAN (1-238): 2.36e-57: 200: 48.32
+	Mm
		665982 PTN6_MOUSE (1-595): 0: 611: 94.45		LIRB3_MOUSE (1-556): 6.52e-58: 210: 30.02
+	Hs
		665819 PTN6_HUMAN (1-595): 0: 628: 100.00		KI2L1_HUMAN (117-337): 5.21e-48: 173: 40.54
+	Hs
		665883 PTN6_HUMAN (1-595): 0: 628: 100.00		PTK7_HUMAN (222-593): 5.98e-31: 130: 12.24
+	Hs
		665820 PTN6_HUMAN (1-595): 0: 628: 100.00		KI2L3_HUMAN (117-334): 1.26e-29: 121: 40.18
+	Mm
		665991 PTN6_MOUSE (1-595): 0: 611: 94.45		LRB4A_MOUSE (111-326): 1.84e-28: 118: 28.18
+	Hs
		665902 PTN6_HUMAN (1-595): 0: 628: 100.00		LAIR1_HUMAN (220-337): 6.27e-13: 71.7: 25.21
+	Mm
		665995 PTN6_MOUSE (1-595): 0: 611: 94.45		LAIR1_MOUSE (16-175): 3.68e-11: 65.9: 23.26
+	Hs
		616999 PTPRD_HUMAN (126-516): 3.18e-114: 376: 29.41		LIRB4_HUMAN (1-238): 2.36e-57: 200: 48.32
+	Hs
		616953 PTPRD_HUMAN (126-516): 3.18e-114: 376: 29.41		KI2L1_HUMAN (117-337): 5.21e-48: 173: 40.54
+	Hs
		1031133 PTPRR_HUMAN (5-515): 1.13e-123: 381: 24.86		PTK7_HUMAN (222-593): 5.98e-31: 130: 12.24
+	Hs
		1069952 PTPRK_HUMAN (72-519): 3.22e-71: 251: 21.06		PXDN_HUMAN (23-342): 4.83e-51: 192: 11.84
+	Hs
		798232 PTN11_HUMAN (2-203): 1.25e-24: 110: 25.23		KI3L1_HUMAN (1-333): 1.59e-66: 225: 38.58
+	Hs
		983479 PTN12_HUMAN (253-530): 7.2e-50: 186: 39.43		PTK7_HUMAN (222-593): 5.98e-31: 130: 12.24
+	Hs
		798139 PTN11_HUMAN (2-203): 1.25e-24: 110: 25.23		KI2L1_HUMAN (117-337): 5.21e-48: 173: 40.54
+	Hs
		985950 PTN11_HUMAN (2-203): 1.25e-24: 110: 25.23		PTK7_HUMAN (222-593): 5.98e-31: 130: 12.24
+	Hs
		798184 PTN11_HUMAN (2-203): 1.25e-24: 110: 25.23		KI2L3_HUMAN (117-334): 1.26e-29: 121: 40.18