HitPredict

Interactor 1: PTN6 (P29350)
Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1)
Gene: PTPN6

Interactor 2: SIGL7 (Q9Y286)
Sialic acid-binding Ig-like lectin 7 (Siglec-7) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (CDw328) (D-siglec) (QA79 membrane protein) (p75) (CD antigen CD328)
Gene: SIGLEC7

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.50	0.585

Property	Details
Experiments	15703304, 15292262, 10499918
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 467
+	Hs
		665971 PTN6_HUMAN (1-595): 0: 628: 100.00		SIGL9_HUMAN (11-467): 5.54e-92: 288: 73.71
+	Hs
		177594 PTN6_HUMAN (1-595): 0: 628: 100.00		SIGL5_HUMAN (39-467): 8.62e-35: 138: 18.74
+	Hs
		665942 PTN6_HUMAN (1-595): 0: 628: 100.00		SIG11_HUMAN (77-466): 5.96e-32: 131: 23.46
+	Hs
		665883 PTN6_HUMAN (1-595): 0: 628: 100.00		PTK7_HUMAN (22-446): 2.06e-31: 130: 11.94
+	Hs
		665940 PTN6_HUMAN (1-595): 0: 628: 100.00		SIG10_HUMAN (77-465): 1.82e-25: 111: 15.13
+	Hs
		589559 PTN6_HUMAN (1-595): 0: 628: 100.00		CD33_HUMAN (145-465): 8.84e-26: 109: 18.38
+	Hs
		590601 PTN6_HUMAN (1-595): 0: 628: 100.00		CD22_HUMAN (31-354): 2.73e-23: 105: 16.31
+	Mm
		665976 PTN6_MOUSE (1-595): 0: 611: 94.45		CD22_MOUSE (20-365): 6.37e-22: 101: 17.61
+	Mm
		56906 PTPRA_MOUSE (125-516): 1.21e-107: 344: 27.14		PTPRF_MOUSE (2-460): 2.9e-56: 203: 13.32
+	Mm
		69645 PTPRA_MOUSE (125-516): 1.21e-107: 344: 27.14		PTPRS_MOUSE (10-460): 8.09e-56: 202: 12.42
+	Mm
		69646 PTPRE_MOUSE (113-516): 9.72e-97: 312: 25.82		PTPRS_MOUSE (10-460): 8.09e-56: 202: 12.42
+	Hs
		1031133 PTPRR_HUMAN (5-515): 1.13e-123: 381: 24.86		PTK7_HUMAN (22-446): 2.06e-31: 130: 11.94
+	Hs
		581462 PTN4_HUMAN (78-519): 2.47e-122: 385: 27.61		VCAM1_HUMAN (107-363): 1.98e-19: 93.3: 18.02
+	Mm
		69654 S4R1M0_MOUSE (118-571): 3.26e-77: 267: 21.19		PTPRS_MOUSE (10-460): 8.09e-56: 202: 12.42
+	Hs
		68228 PTPRS_HUMAN (108-516): 3.34e-114: 376: 27.93		HECA2_HUMAN (28-374): 1.87e-19: 92.6: 17.88
+	Hs
		1069962 PTPRK_HUMAN (72-519): 3.22e-71: 251: 21.06		LRIG1_HUMAN (25-435): 1.06e-60: 216: 15.60
+	Hs
		68222 PTPRF_HUMAN (93-516): 1.07e-112: 372: 26.98		HECA2_HUMAN (28-374): 1.87e-19: 92.6: 17.88
+	Hs
		441175 PTPRC_HUMAN (118-575): 2.27e-82: 283: 20.20		CD22_HUMAN (31-354): 2.73e-23: 105: 16.31
+	Hs
		1069952 PTPRK_HUMAN (72-519): 3.22e-71: 251: 21.06		PXDN_HUMAN (245-451): 2.12e-23: 105: 10.57
+	Hs
		983479 PTN12_HUMAN (253-530): 7.2e-50: 186: 39.43		PTK7_HUMAN (22-446): 2.06e-31: 130: 11.94