HitPredict

Interactor 1: PTN6 (P29351)
Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (70Z-SHP) (Hematopoietic cell protein-tyrosine phosphatase) (PTPTY-42) (Protein-tyrosine phosphatase 1C) (PTP-1C) (SH-PTP1) (SHP-1)
Gene: Ptpn6

Interactor 2: LIRB3 (P97484)
Leukocyte immunoglobulin-like receptor subfamily B member 3 (LIR-3) (Leukocyte immunoglobulin-like receptor 3) (Cell-surface glycoprotein p91) (Paired immunoglobulin-like receptor B) (PIR-B)
Gene: Lilrb3

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.721

Property	Details
Experiments	22660330, 11812650, 20398663, 18316626, 19687229, 19684158
Identification Methods	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0019221 - cytokine-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Mm			1 841
+	Hs
		665916 PTN6_HUMAN (1-595): 0: 639: 94.45		LIRB2_HUMAN (1-441): 1.67e-91: 302: 36.69
+	Hs
		665821 PTN6_HUMAN (1-595): 0: 639: 94.45		KI3L1_HUMAN (419-834): 9.5e-72: 244: 23.46
+	Hs
		665820 PTN6_HUMAN (1-595): 0: 639: 94.45		KI2L3_HUMAN (520-832): 1.61e-42: 160: 21.70
+	Hs
		665819 PTN6_HUMAN (1-595): 0: 639: 94.45		KI2L1_HUMAN (520-834): 1.06e-37: 146: 21.63
+	Hs
		665883 PTN6_HUMAN (1-595): 0: 639: 94.45		PTK7_HUMAN (318-841): 8.38e-35: 145: 11.26
+	Hs
		665922 PTN6_HUMAN (1-595): 0: 639: 94.45		LIRB1_HUMAN (410-835): 4.76e-26: 116: 18.99
+	Mm
		665991 PTN6_MOUSE (1-595): 0: 634: 100.00		LRB4A_MOUSE (116-324): 1.64e-27: 116: 24.07
+	Hs
		252776 PTN6_HUMAN (1-595): 0: 639: 94.45		LIRB3_HUMAN (21-228): 1.37e-22: 105: 32.86
+	Mm
		665976 PTN6_MOUSE (1-595): 0: 634: 100.00		CD22_MOUSE (2-225): 8.65e-23: 106: 16.09
+	Hs
		557436 PTN6_HUMAN (1-595): 0: 639: 94.45		PECA1_HUMAN (35-617): 1.09e-20: 99.8: 17.31
+	Hs
		665921 PTN6_HUMAN (1-595): 0: 639: 94.45		LIRB4_HUMAN (23-137): 1.51e-17: 88.4: 29.17
+	Hs
		590601 PTN6_HUMAN (1-595): 0: 639: 94.45		CD22_HUMAN (356-660): 2.07e-16: 86.1: 16.03
+	Hs
		665902 PTN6_HUMAN (1-595): 0: 639: 94.45		LAIR1_HUMAN (122-234): 6.64e-11: 65.9: 28.07
+	Mm
		665995 PTN6_MOUSE (1-595): 0: 634: 100.00		LAIR1_MOUSE (1-176): 3.31e-12: 69.4: 25.77
+	Hs
		131993 PTPRA_HUMAN (31-516): 8.4e-124: 385: 22.47		NCHL1_HUMAN (26-829): 2.35e-61: 227: 9.98
+	Gg
		47583 A0A8V0YWD3_CHICK (31-516): 1.3e-123: 387: 23.02		CNTN1_CHICK (36-833): 3.17e-54: 205: 9.93
+	Hs
		616953 PTPRD_HUMAN (34-516): 1.72e-125: 408: 25.00		KI2L1_HUMAN (520-834): 1.06e-37: 146: 21.63
+	Hs
		616999 PTPRD_HUMAN (34-516): 1.72e-125: 408: 25.00		LIRB4_HUMAN (23-137): 1.51e-17: 88.4: 29.17
+	Hs
		617163 PTPRZ_HUMAN (34-529): 1.34e-73: 258: 18.44		CNTN1_HUMAN (25-825): 1.24e-56: 212: 9.88
+	Hs
		441175 PTPRC_HUMAN (31-591): 5.08e-93: 313: 18.42		CD22_HUMAN (356-660): 2.07e-16: 86.1: 16.03