HitPredict

Interactor 1: PTN6 (P29351)
Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (70Z-SHP) (Hematopoietic cell protein-tyrosine phosphatase) (PTPTY-42) (Protein-tyrosine phosphatase 1C) (PTP-1C) (SH-PTP1) (SHP-1)
Gene: Ptpn6

Interactor 2: JAK2 (Q62120)
Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)
Gene: JAK2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.38 1.00 0.618

The method score is based on:

Property Details
Experiments 9111009
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains FERM_F1~SH2, PK_Tyr_Ser-Thr~SH2, SH2~SH2, PK_Tyr_Ser-Thr~Y_phosphatase, SH2~Y_phosphatase
Common GO terms GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0008284 - positive regulation of cell population proliferation
GO:0019221 - cytokine-mediated signaling pathway
and 5 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 595
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024