HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: LTK (P29376)
Leukocyte tyrosine kinase receptor (EC 2.7.10.1) (Protein tyrosine kinase 1)
Gene: LTK

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	7650032, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 864
+	Hs
		666189 SHC1_HUMAN (1-583): 0: 531: 100.00		ALK_HUMAN (4-851): 0: 701: 54.51
+	Mm
		956924 SHC1_MOUSE (1-583): 0: 527: 94.51		ALK_MOUSE (4-851): 0: 696: 53.82
+	Hs
		434141 SHC1_HUMAN (1-583): 0: 531: 100.00		RET_HUMAN (278-849): 5.71e-146: 461: 25.98
+	Hs
		601467 SHC1_HUMAN (1-583): 0: 531: 100.00		FGFR2_HUMAN (163-833): 6.48e-137: 429: 20.03
+	Hs
		666116 SHC1_HUMAN (1-583): 0: 531: 100.00		ERBB4_HUMAN (277-847): 5.2e-131: 425: 21.37
+	Hs
		435550 SHC1_HUMAN (1-583): 0: 531: 100.00		IGF1R_HUMAN (298-854): 3.35e-128: 419: 27.39
+	Hs
		411312 SHC1_HUMAN (1-583): 0: 531: 100.00		INSR_HUMAN (367-837): 3.2e-121: 400: 30.82
+	Hs
		666048 SHC1_HUMAN (1-583): 0: 531: 100.00		EPHA5_HUMAN (389-809): 8.73e-124: 400: 26.02
+	Hs
		507872 SHC1_HUMAN (1-583): 0: 531: 100.00		FGFR1_HUMAN (333-827): 2.64e-122: 390: 24.42
+	Hs
		665145 SHC1_HUMAN (1-583): 0: 531: 100.00		EPHA2_HUMAN (446-813): 2.21e-109: 360: 30.38
+	Hs
		434220 SHC4_HUMAN (7-581): 1.07e-136: 413: 45.53		RET_HUMAN (278-849): 5.71e-146: 461: 25.98
+	Rn
		1129188 SHC1_RAT (111-583): 1.45e-142: 422: 94.72		Q9QX70_RAT (245-864): 4.23e-128: 416: 20.09
+	Hs
		666119 SHC1_HUMAN (1-583): 0: 531: 100.00		NTRK2_HUMAN (475-778): 2.43e-61: 224: 38.07
+	Hs
		384331 SHC1_HUMAN (1-583): 0: 531: 100.00		NTRK1_HUMAN (502-786): 7.75e-60: 220: 41.64
+	Mm
		957230 SHC1_MOUSE (1-583): 0: 527: 94.51		NTRK1_MOUSE (502-784): 2.3e-60: 221: 41.24
+	Hs
		666032 SHC1_HUMAN (1-583): 0: 531: 100.00		TEC_HUMAN (504-777): 1.34e-56: 207: 41.52
+	Hs
		666117 SHC1_HUMAN (1-583): 0: 531: 100.00		NTRK3_HUMAN (502-778): 1.77e-54: 205: 36.76
+	Rn
		1129187 SHC1_RAT (111-583): 1.45e-142: 422: 94.72		NTRK2_RAT (475-778): 1.09e-60: 223: 38.07
+	Rn
		728445 SHC1_RAT (111-583): 1.45e-142: 422: 94.72		NTRK1_RAT (502-784): 2.42e-60: 221: 41.24
+	Hs
		385029 SHC4_HUMAN (7-581): 1.07e-136: 413: 45.53		NTRK1_HUMAN (502-786): 7.75e-60: 220: 41.64