HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: IL3RB (P32927)
Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131)
Gene: CSF2RB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.683

Property	Details
Experiments	15194700, 10704825, 8647804, 16437163
Identification Methods	affinity chromatography technology, pull down, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 897
+	Hs
		655234 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		IL3RB_HUMAN (1-897): 0: 586: 100.00
+	Hs
		622723 SHC1_HUMAN (1-583): 0: 531: 100.00		IL4RA_HUMAN (233-881): 1.57e-46: 181: 16.60
+	Hs
		666008 SHC1_HUMAN (1-583): 0: 531: 100.00		IL2RG_HUMAN (245-547): 1.1e-48: 179: 20.06
+	Hs
		666027 SHC1_HUMAN (1-583): 0: 531: 100.00		IL6RB_HUMAN (238-477): 3.46e-44: 174: 18.22
+	Mm
		557514 SHC1_MOUSE (1-583): 0: 527: 94.51		IL2RB_MOUSE (248-718): 3.05e-39: 155: 17.06
+	Hs
		581152 SHC1_HUMAN (1-583): 0: 531: 100.00		EPOR_HUMAN (245-684): 4.09e-38: 151: 18.36
+	Hs
		540447 SHC1_HUMAN (1-583): 0: 531: 100.00		IL2RB_HUMAN (248-745): 2.62e-37: 150: 15.62
+	Hs
		548790 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		CSF2R_HUMAN (122-479): 7.49e-79: 263: 14.25
+	Hs
		548629 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		PRLR_HUMAN (238-732): 1.03e-48: 185: 15.21
+	Hs
		557611 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		IL3RA_HUMAN (173-505): 9.99e-64: 221: 16.52
+	Hs
		548653 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		IL6RB_HUMAN (238-477): 3.46e-44: 174: 18.22
+	Hs
		548635 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		EPOR_HUMAN (245-684): 4.09e-38: 151: 18.36
+	Hs
		560471 VAV2_HUMAN (189-579): 1.9e-42: 165: 12.97		PRLR_HUMAN (238-732): 1.03e-48: 185: 15.21
+	Hs
		442787 HCK_HUMAN (348-575): 2.72e-43: 164: 17.16		IL6RB_HUMAN (238-477): 3.46e-44: 174: 18.22
+	Hs
		682264 SHB_HUMAN (369-579): 2.01e-41: 158: 20.63		IL2RG_HUMAN (245-547): 1.1e-48: 179: 20.06
+	Hs
		655246 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		IL6RB_HUMAN (238-477): 3.46e-44: 174: 18.22
+	Hs
		540464 SHB_HUMAN (369-579): 2.01e-41: 158: 20.63		IL2RB_HUMAN (248-745): 2.62e-37: 150: 15.62
+	Mm
		540266 P85A_MOUSE (300-581): 6.66e-38: 151: 15.99		EPOR_MOUSE (216-630): 1.13e-39: 156: 17.10
+	Hs
		581150 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		EPOR_HUMAN (245-684): 4.09e-38: 151: 18.36
+	Hs
		540445 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		IL2RB_HUMAN (248-745): 2.62e-37: 150: 15.62