HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: IL6RB (P40189)
Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
Gene: IL6ST

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	9126968
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	SH2~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0008284 - positive regulation of cell population proliferation GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 918
+	Hs
		666159 SHC1_HUMAN (1-583): 0: 531: 100.00		CSF3R_HUMAN (1-818): 1.84e-103: 342: 24.91
+	Mm
		770715 SHC1_MOUSE (1-583): 0: 527: 94.51		CSF3R_MOUSE (1-793): 1.35e-98: 329: 22.33
+	Hs
		548653 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		IL6RB_HUMAN (1-918): 0: 623: 100.00
+	Hs
		442787 HCK_HUMAN (348-575): 2.72e-43: 164: 17.16		IL6RB_HUMAN (1-918): 0: 623: 100.00
+	Hs
		655246 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		IL6RB_HUMAN (1-918): 0: 623: 100.00
+	Hs
		770194 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		IL6RB_HUMAN (1-918): 0: 623: 100.00
+	Hs
		442875 HCK_HUMAN (348-575): 2.72e-43: 164: 17.16		CSF3R_HUMAN (1-818): 1.84e-103: 342: 24.91
+	Mm
		435879 HCK_MOUSE (348-582): 2.92e-40: 155: 19.11		CSF3R_MOUSE (1-793): 1.35e-98: 329: 22.33
+	Hs
		489988 SH2D3_HUMAN (333-582): 8.25e-40: 157: 23.55		PTPRF_HUMAN (32-733): 1.82e-83: 296: 14.38
+	Hs
		548629 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		PRLR_HUMAN (124-351): 1.32e-50: 190: 25.83
+	Hs
		616962 BMX_HUMAN (341-582): 1.11e-38: 153: 19.69		PTPRD_HUMAN (1-897): 2.19e-59: 223: 11.86
+	Hs
		560471 VAV2_HUMAN (189-579): 1.9e-42: 165: 12.97		PRLR_HUMAN (124-351): 1.32e-50: 190: 25.83
+	Mm
		524116 ANS1B_MOUSE (39-364): 1.02e-45: 175: 17.86		CNTN1_MOUSE (27-915): 1.35e-45: 179: 9.77
+	Hs
		557612 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		CNTFR_HUMAN (39-326): 4.17e-50: 183: 22.11
+	Mm
		936320 ANS1B_MOUSE (39-364): 1.02e-45: 175: 17.86		DCC_MOUSE (6-623): 1.99e-37: 154: 11.45
+	Hs
		557632 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		DCC_HUMAN (6-623): 1.2e-36: 152: 11.45
+	Mm
		69652 ANS1B_MOUSE (39-364): 1.02e-45: 175: 17.86		PTPRS_MOUSE (250-785): 3.31e-18: 92.7: 11.99
+	Hs
		645942 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		CNTFR_HUMAN (39-326): 4.17e-50: 183: 22.11
+	Hs
		855816 VAV2_HUMAN (189-579): 1.9e-42: 165: 12.97		TITIN_HUMAN (16-496): 1.42e-10: 67.7: 8.82
+	Hs
		817315 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		LEPR_HUMAN (295-801): 5.68e-14: 78.5: 12.94