HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: CSK (P41240)
Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)
Gene: CSK

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	12048194, 19380743
Identification Methods	pull down, affinity chromatography technology, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 450
+	Hs
		337362 SHC1_HUMAN (1-583): 0: 531: 100.00		ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83
+	Hs
		69203 SHC1_HUMAN (1-583): 0: 531: 100.00		A9UF07_HUMAN (5-447): 2.25e-159: 494: 37.83
+	Hs
		412038 SHC1_HUMAN (1-583): 0: 531: 100.00		FYN_HUMAN (12-442): 1.26e-170: 491: 36.77
+	Hs
		522805 SHC1_HUMAN (1-583): 0: 531: 100.00		SRC_HUMAN (12-442): 8.48e-171: 491: 39.33
+	Hs
		433266 SHC1_HUMAN (1-583): 0: 531: 100.00		YES_HUMAN (12-442): 5.99e-170: 490: 37.30
+	Hs
		666033 SHC1_HUMAN (1-583): 0: 531: 100.00		ABL2_HUMAN (4-443): 1.63e-160: 485: 39.33
+	Mm
		403430 SHC1_MOUSE (1-583): 0: 527: 94.51		SRC_MOUSE (12-442): 1.93e-169: 488: 39.55
+	Hs
		433604 SHC1_HUMAN (1-583): 0: 531: 100.00		LYN_HUMAN (4-445): 3.75e-160: 463: 37.12
+	Hs
		666032 SHC1_HUMAN (1-583): 0: 531: 100.00		TEC_HUMAN (8-450): 6.4e-150: 442: 36.96
+	Mm
		403451 SHC2_MOUSE (43-582): 6.38e-127: 386: 45.91		SRC_MOUSE (12-442): 1.93e-169: 488: 39.55
+	Mm
		403440 SHC3_MOUSE (128-582): 1.14e-111: 343: 53.26		SRC_MOUSE (12-442): 1.93e-169: 488: 39.55
+	Hs
		442828 GRB14_HUMAN (66-579): 1.66e-73: 246: 14.41		HCK_HUMAN (3-445): 6.38e-167: 481: 36.32
+	Hs
		337333 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83
+	Hs
		411981 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		FYN_HUMAN (12-442): 1.26e-170: 491: 36.77
+	Hs
		411580 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		LCK_HUMAN (5-443): 1.95e-168: 485: 38.55
+	Hs
		337531 SHD_HUMAN (328-582): 1.62e-47: 171: 23.02		ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83
+	Hs
		412098 VAV2_HUMAN (189-579): 1.9e-42: 165: 12.97		FYN_HUMAN (12-442): 1.26e-170: 491: 36.77
+	Hs
		548654 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		TEC_HUMAN (8-450): 6.4e-150: 442: 36.96
+	Hs
		209000 NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83		TXK_HUMAN (10-443): 4.44e-159: 461: 36.75
+	Ce
		106650 CED6_CAEEL (123-481): 2.83e-45: 169: 15.10		SRC1_CAEEL (10-442): 3.37e-156: 454: 35.97