HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: TEC (P42680)
Tyrosine-protein kinase Tec (EC 2.7.10.2)
Gene: TEC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005543 - phospholipid binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 631
+	Hs
		337362 SHC1_HUMAN (1-583): 0: 531: 100.00		ABL1_HUMAN (143-624): 2.71e-169: 514: 37.30
+	Hs
		666033 SHC1_HUMAN (1-583): 0: 531: 100.00		ABL2_HUMAN (124-631): 7.96e-168: 512: 36.59
+	Hs
		69203 SHC1_HUMAN (1-583): 0: 531: 100.00		A9UF07_HUMAN (144-624): 2.59e-163: 512: 37.17
+	Hs
		522805 SHC1_HUMAN (1-583): 0: 531: 100.00		SRC_HUMAN (127-627): 2.29e-166: 487: 35.24
+	Mm
		403430 SHC1_MOUSE (1-583): 0: 527: 94.51		SRC_MOUSE (104-627): 5.05e-166: 486: 33.77
+	Hs
		433266 SHC1_HUMAN (1-583): 0: 531: 100.00		YES_HUMAN (111-627): 3.51e-163: 479: 34.08
+	Hs
		412038 SHC1_HUMAN (1-583): 0: 531: 100.00		FYN_HUMAN (165-627): 5.66e-161: 473: 36.83
+	Hs
		433604 SHC1_HUMAN (1-583): 0: 531: 100.00		LYN_HUMAN (145-627): 8.36e-153: 452: 34.68
+	Hs
		666029 SHC1_HUMAN (1-583): 0: 531: 100.00		CSK_HUMAN (179-626): 3.34e-152: 448: 37.28
+	Hs
		548654 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		TEC_HUMAN (1-631): 0: 738: 100.00
+	Mm
		403451 SHC2_MOUSE (43-582): 6.38e-127: 386: 45.91		SRC_MOUSE (104-627): 5.05e-166: 486: 33.77
+	Mm
		403440 SHC3_MOUSE (128-582): 1.14e-111: 343: 53.26		SRC_MOUSE (104-627): 5.05e-166: 486: 33.77
+	Hs
		548690 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		BTK_HUMAN (5-627): 0: 629: 52.50
+	Hs
		442828 GRB14_HUMAN (66-579): 1.66e-73: 246: 14.41		HCK_HUMAN (98-628): 1.96e-161: 474: 34.02
+	Hs
		337333 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		ABL1_HUMAN (143-624): 2.71e-169: 514: 37.30
+	Hs
		337531 SHD_HUMAN (328-582): 1.62e-47: 171: 23.02		ABL1_HUMAN (143-624): 2.71e-169: 514: 37.30
+	Hs
		411981 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		FYN_HUMAN (165-627): 5.66e-161: 473: 36.83
+	Ce
		106650 CED6_CAEEL (123-481): 2.83e-45: 169: 15.10		SRC1_CAEEL (180-627): 3.29e-170: 497: 34.79
+	Hs
		411580 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		LCK_HUMAN (151-627): 2.3e-158: 466: 35.34
+	Hs
		412098 VAV2_HUMAN (189-579): 1.9e-42: 165: 12.97		FYN_HUMAN (165-627): 5.66e-161: 473: 36.83