HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: ZAP70 (P43403)
Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase)
Gene: ZAP70

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.888

Property	Details
Experiments	8235613, 9685404, 23267066, 15688026
Identification Methods	unspecified method, affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 619
+	Hs
		666035 SHC1_HUMAN (1-583): 0: 531: 100.00		KSYK_HUMAN (1-600): 0: 554: 53.58
+	Hs
		796480 SHC3_HUMAN (6-582): 3.32e-127: 387: 45.47		ZAP70_HUMAN (1-619): 0: 641: 100.00
+	Hs
		665145 SHC1_HUMAN (1-583): 0: 531: 100.00		EPHA2_HUMAN (20-614): 3.34e-152: 465: 22.71
+	Hs
		666033 SHC1_HUMAN (1-583): 0: 531: 100.00		ABL2_HUMAN (120-617): 2.51e-147: 457: 29.14
+	Hs
		69203 SHC1_HUMAN (1-583): 0: 531: 100.00		A9UF07_HUMAN (120-601): 1.71e-141: 452: 29.49
+	Hs
		522805 SHC1_HUMAN (1-583): 0: 531: 100.00		SRC_HUMAN (73-607): 2.65e-149: 443: 25.14
+	Hs
		412038 SHC1_HUMAN (1-583): 0: 531: 100.00		FYN_HUMAN (62-607): 2.84e-147: 438: 24.87
+	Mm
		403430 SHC1_MOUSE (1-583): 0: 527: 94.51		SRC_MOUSE (73-607): 4.37e-148: 440: 25.14
+	Hs
		666049 SHC1_HUMAN (1-583): 0: 531: 100.00		EPHA4_HUMAN (72-616): 4.07e-141: 436: 24.65
+	Hs
		666032 SHC1_HUMAN (1-583): 0: 531: 100.00		TEC_HUMAN (95-598): 1.98e-140: 424: 25.68
+	Hs
		337362 SHC1_HUMAN (1-583): 0: 531: 100.00		ABL1_HUMAN (90-601): 9.22e-135: 423: 26.31
+	Hs
		433266 SHC1_HUMAN (1-583): 0: 531: 100.00		YES_HUMAN (111-607): 1.3e-140: 421: 24.35
+	Hs
		666029 SHC1_HUMAN (1-583): 0: 531: 100.00		CSK_HUMAN (90-599): 3.17e-140: 417: 27.41
+	Hs
		433604 SHC1_HUMAN (1-583): 0: 531: 100.00		LYN_HUMAN (75-608): 2.44e-137: 412: 24.72
+	Mm
		403451 SHC2_MOUSE (43-582): 6.38e-127: 386: 45.91		SRC_MOUSE (73-607): 4.37e-148: 440: 25.14
+	Mm
		403440 SHC3_MOUSE (128-582): 1.14e-111: 343: 53.26		SRC_MOUSE (73-607): 4.37e-148: 440: 25.14
+	Hs
		666080 SHC1_HUMAN (1-583): 0: 531: 100.00		FAK1_HUMAN (344-593): 1.41e-59: 217: 43.03
+	Hs
		442828 GRB14_HUMAN (66-579): 1.66e-73: 246: 14.41		HCK_HUMAN (43-608): 6.8e-143: 426: 23.69
+	Hs
		337333 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		ABL1_HUMAN (90-601): 9.22e-135: 423: 26.31
+	Mm
		815728 SHC1_MOUSE (1-583): 0: 527: 94.51		KSYK_MOUSE (153-266): 1.5e-09: 63.1: 29.57