HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: PAXI (P49023)
Paxillin
Gene: PXN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	31980649, 34079125, unassigned2173
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 583 Hs			1 591
+	Hs
		209008 NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Hs
		442793 HCK_HUMAN (348-575): 2.72e-43: 164: 17.16		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Hs
		557639 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Hs
		275552 BCAR3_HUMAN (379-583): 3.82e-38: 152: 23.83		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Hs
		823365 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Hs
		1115791 Q49AR9_HUMAN (40-425): 1.96e-47: 176: 18.14		FHL5_HUMAN (381-590): 9.47e-63: 210: 29.44
+	Hs
		1136597 ANS1A_HUMAN (40-393): 2.28e-42: 165: 18.41		FHL5_HUMAN (381-590): 9.47e-63: 210: 29.44
+	Hs
		442845 HCK_HUMAN (348-575): 2.72e-43: 164: 17.16		FHL5_HUMAN (381-590): 9.47e-63: 210: 29.44
+	Hs
		1044610 SHE_HUMAN (357-583): 9.82e-38: 148: 21.40		FHL3_HUMAN (382-590): 1.13e-57: 196: 28.64
+	Hs
		209005 NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83		LIMS1_HUMAN (346-529): 1.14e-43: 160: 32.97
+	Hs
		442827 HCK_HUMAN (348-575): 2.72e-43: 164: 17.16		FHL2_HUMAN (329-467): 4.35e-25: 107: 25.87
+	Hs
		150515 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		ABLM1_HUMAN (512-590): 6.08e-10: 64.4: 25.32
+	Hs
		150611 Q96D37_HUMAN (163-578): 1.11e-54: 200: 12.25		ABLM1_HUMAN (512-590): 6.08e-10: 64.4: 25.32
+	Hs
		1234542 SH2D3_HUMAN (333-582): 8.25e-40: 157: 23.55		LPP_HUMAN (472-590): 5.36e-23: 105: 26.23
+	Hs
		300996 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		ABLM3_HUMAN (416-590): 1.41e-40: 158: 29.03
+	Hs
		1234547 SH2D3_HUMAN (333-582): 8.25e-40: 157: 23.55		PDLI5_HUMAN (530-590): 3.57e-11: 68: 34.43
+	Hs
		924889 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		PDLI7_HUMAN (473-590): 2.88e-34: 137: 33.90
+	Hs
		150552 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		ABLM1_HUMAN (512-590): 6.08e-10: 64.4: 25.32