HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005159 - insulin-like growth factor receptor binding GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0030971 - receptor tyrosine kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 247
+	Hs
		666056 SHC1_HUMAN (1-583): 0: 531: 100.00		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		666059 SHC1_HUMAN (1-583): 0: 531: 100.00		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		666010 SHC1_HUMAN (1-583): 0: 531: 100.00		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16
+	Hs
		909875 ANS1A_HUMAN (40-393): 2.28e-42: 165: 18.41		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		904939 ANS1A_HUMAN (40-393): 2.28e-42: 165: 18.41		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	Hs
		850732 BMX_HUMAN (341-582): 1.11e-38: 153: 19.69		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		655301 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		904593 SHB_HUMAN (369-579): 2.01e-41: 158: 20.63		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	Hs
		904855 SH2D3_HUMAN (333-582): 8.25e-40: 157: 23.55		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	Hs
		982351 ANS1A_HUMAN (40-393): 2.28e-42: 165: 18.41		1433F_HUMAN (1-246): 2.5e-135: 382: 86.99
+	Hs
		655299 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	Mm
		140059 P85B_MOUSE (358-581): 2.77e-30: 128: 16.67		1433E_MOUSE (1-244): 2.02e-141: 398: 63.53
+	Hs
		683592 ANS1A_HUMAN (40-393): 2.28e-42: 165: 18.41		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		927366 ANS1A_HUMAN (40-393): 2.28e-42: 165: 18.41		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		927304 SH2D3_HUMAN (333-582): 8.25e-40: 157: 23.55		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		647160 ANS1A_HUMAN (40-393): 2.28e-42: 165: 18.41		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		655308 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		684244 ANS1A_HUMAN (40-393): 2.28e-42: 165: 18.41		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16
+	Hs
		683911 BMX_HUMAN (341-582): 1.11e-38: 153: 19.69		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16
+	Hs
		684034 GRB7_HUMAN (371-563): 3.91e-33: 135: 21.57		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16