HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: SHC2 (P98077)
SHC-transforming protein 2 (Protein Sck) (SHC-transforming protein B) (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2)
Gene: SHC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PID~PID, SH2~SH2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030971 - receptor tyrosine kinase binding GO:0035556 - intracellular signal transduction
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 583 Hs			1 582
+	Hs
		666002 SHC1_HUMAN (1-583): 0: 531: 100.00		SHC1_HUMAN (1-581): 2.34e-124: 379: 45.41
+	Mm
		957225 SHC1_MOUSE (1-583): 0: 527: 94.51		SHC1_MOUSE (1-581): 6.16e-124: 378: 44.89
+	Hs
		1164327 SHC4_HUMAN (7-581): 1.07e-136: 413: 45.53		SHC3_HUMAN (82-581): 1.27e-122: 375: 49.71
+	Hs
		666133 SHC1_HUMAN (1-583): 0: 531: 100.00		ANS1B_HUMAN (26-360): 3.45e-51: 192: 13.11
+	Hs
		666145 SHC1_HUMAN (1-583): 0: 531: 100.00		ANS1A_HUMAN (34-384): 4.52e-50: 188: 14.91
+	Hs
		433266 SHC1_HUMAN (1-583): 0: 531: 100.00		YES_HUMAN (330-573): 5.09e-39: 152: 16.41
+	Hs
		522805 SHC1_HUMAN (1-583): 0: 531: 100.00		SRC_HUMAN (326-573): 4.48e-39: 152: 15.06
+	Hs
		145973 SHC1_HUMAN (1-583): 0: 531: 100.00		SH2B2_HUMAN (299-581): 3.55e-37: 148: 18.62
+	Mm
		403430 SHC1_MOUSE (1-583): 0: 527: 94.51		SRC_MOUSE (341-573): 3.33e-38: 149: 15.98
+	Hs
		655224 SHC1_HUMAN (1-583): 0: 531: 100.00		P85A_HUMAN (427-578): 3.1e-23: 106: 19.23
+	Mm
		643078 SHC1_MOUSE (1-583): 0: 527: 94.51		P85A_MOUSE (427-578): 3.1e-23: 106: 19.23
+	Hs
		99741 SHC3_HUMAN (6-582): 3.32e-127: 387: 45.47		F5H5M1_HUMAN (247-580): 8.71e-71: 233: 40.97
+	Hs
		666057 SHC1_HUMAN (1-583): 0: 531: 100.00		GRB2_HUMAN (475-582): 5.69e-16: 79.1: 28.07
+	Mm
		957235 SHC1_MOUSE (1-583): 0: 527: 94.51		GRB2_MOUSE (475-582): 4.98e-16: 79.1: 27.68
+	Rn
		924995 SHC1_RAT (111-583): 1.45e-142: 422: 94.72		GRB2_RAT (475-582): 1.32e-32: 126: 28.07
+	Mm
		403451 SHC2_MOUSE (43-582): 6.38e-127: 386: 45.91		SRC_MOUSE (341-573): 3.33e-38: 149: 15.98
+	Hs
		855787 SHC2_HUMAN (56-582): 4.56e-116: 358: 44.88		VAV2_HUMAN (380-578): 2.05e-36: 147: 13.74
+	Hs
		655429 SHC3_HUMAN (6-582): 3.32e-127: 387: 45.47		P85A_HUMAN (427-578): 3.1e-23: 106: 19.23
+	Hs
		924646 SHC4_HUMAN (7-581): 1.07e-136: 413: 45.53		GRB2_HUMAN (475-582): 5.69e-16: 79.1: 28.07