HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: PTN12 (Q05209)
Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)
Gene: PTPN12

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.983

Property	Details
Experiments	7929214, 27880917, 28514442, 28675297, 8626541, 24412244, 33961781, 24189400, 31980649, 19380743, unassigned2173
Identification Methods	two hybrid, affinity chromatography technology, proximity labelling technology, pull down, anti tag coimmunoprecipitation, tandem affinity purification, two hybrid array
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	SH2~Y_phosphatase
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 780
+	Mm
		728827 SHC1_MOUSE (1-583): 0: 527: 94.51		PTN12_MOUSE (1-780): 0: 560: 83.10
+	Hs
		666083 SHC1_HUMAN (1-583): 0: 531: 100.00		PTN11_HUMAN (7-351): 1.65e-124: 387: 31.48
+	Mm
		719296 SHC1_MOUSE (1-583): 0: 527: 94.51		PTN11_MOUSE (7-351): 2.04e-124: 387: 31.48
+	Hs
		570484 SHC1_HUMAN (1-583): 0: 531: 100.00		PTN2_HUMAN (24-401): 2.72e-123: 377: 23.85
+	Hs
		576989 SHC1_HUMAN (1-583): 0: 531: 100.00		PTPRA_HUMAN (7-295): 5.6e-105: 342: 32.08
+	Hs
		617042 SHC1_HUMAN (1-583): 0: 531: 100.00		PTPRE_HUMAN (7-295): 3.58e-101: 329: 31.54
+	Mm
		828096 SHC1_MOUSE (1-583): 0: 527: 94.51		PTPRE_MOUSE (7-295): 8.44e-100: 325: 31.21
+	Hs
		985979 SHC4_HUMAN (7-581): 1.07e-136: 413: 45.53		PTN11_HUMAN (7-351): 1.65e-124: 387: 31.48
+	Hs
		209035 NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83		PTN12_HUMAN (1-780): 0: 586: 100.00
+	Hs
		557665 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		PTN12_HUMAN (1-780): 0: 586: 100.00
+	Mm
		420370 VAV_MOUSE (163-579): 6.29e-54: 198: 11.54		PTPRC_MOUSE (13-686): 9.35e-150: 472: 18.93
+	Hs
		548767 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		PTN22_HUMAN (1-779): 6.27e-132: 413: 32.01
+	Hs
		548649 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		PTN6_HUMAN (7-361): 1.95e-132: 407: 31.25
+	Hs
		208991 NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83		PTPRA_HUMAN (7-295): 5.6e-105: 342: 32.08
+	Hs
		577024 SHB_HUMAN (369-579): 2.01e-41: 158: 20.63		PTPRA_HUMAN (7-295): 5.6e-105: 342: 32.08
+	Hs
		576988 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		PTPRA_HUMAN (7-295): 5.6e-105: 342: 32.08
+	Mm
		69652 ANS1B_MOUSE (39-364): 1.02e-45: 175: 17.86		PTPRS_MOUSE (8-299): 2.53e-90: 313: 31.99
+	Hs
		616962 BMX_HUMAN (341-582): 1.11e-38: 153: 19.69		PTPRD_HUMAN (8-299): 1.81e-94: 325: 32.32
+	Hs
		489988 SH2D3_HUMAN (333-582): 8.25e-40: 157: 23.55		PTPRF_HUMAN (8-299): 2.83e-90: 313: 31.99
+	Mm
		82788 ANS1B_MOUSE (39-364): 1.02e-45: 175: 17.86		PTPRZ_MOUSE (51-293): 2.2e-20: 99.4: 28.00