HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: CALD1 (Q05682)
Caldesmon (CDM)
Gene: CALD1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	10559276
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001525 - angiogenesis GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 793
+	Hs
		666019 SHC1_HUMAN (1-583): 0: 531: 100.00		MYH10_HUMAN (55-788): 1.22e-26: 119: 10.63
+	Hs
		666020 SHC1_HUMAN (1-583): 0: 531: 100.00		MYH11_HUMAN (2-686): 1.62e-23: 109: 9.77
+	Hs
		666018 SHC1_HUMAN (1-583): 0: 531: 100.00		MYH9_HUMAN (2-631): 8.69e-22: 103: 10.87
+	Mm
		1206702 ANS1B_MOUSE (39-364): 1.02e-45: 175: 17.86		ITSN1_MOUSE (241-644): 2.58e-29: 127: 22.77
+	Hs
		1068630 Q96D37_HUMAN (163-578): 1.11e-54: 200: 12.25		PLEC_HUMAN (5-781): 2.36e-17: 89.5: 9.94
+	Hs
		548710 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		PLEC_HUMAN (5-781): 2.36e-17: 89.5: 9.94
+	Mm
		936588 ANS1B_MOUSE (39-364): 1.02e-45: 175: 17.86		ROCK2_MOUSE (1-688): 4.34e-24: 111: 11.48
+	Hs
		528420 SHD_HUMAN (328-582): 1.62e-47: 171: 23.02		MYH8_HUMAN (1-687): 6.45e-24: 110: 11.87
+	Hs
		275589 BCAR3_HUMAN (379-583): 3.82e-38: 152: 23.83		MY18A_HUMAN (9-628): 1.86e-28: 125: 15.98
+	Hs
		655386 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		ITSN1_HUMAN (235-636): 6.18e-27: 120: 21.34
+	Dm
		112569 NUMB_DROME (117-466): 1.02e-43: 165: 15.86		M9ND00_DROME (260-532): 4.57e-21: 101: 16.85
+	Hs
		551599 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		DESP_HUMAN (13-640): 3.03e-22: 105: 14.35
+	Hs
		426943 FES_HUMAN (326-581): 1.46e-37: 150: 21.79		DESP_HUMAN (13-640): 3.03e-22: 105: 14.35
+	Hs
		129221 P85B_HUMAN (358-581): 2.69e-29: 125: 17.47		MYH10_HUMAN (55-788): 1.22e-26: 119: 10.63
+	Hs
		426959 FES_HUMAN (326-581): 1.46e-37: 150: 21.79		PLEC_HUMAN (5-781): 2.36e-17: 89.5: 9.94
+	Hs
		129220 P85B_HUMAN (358-581): 2.69e-29: 125: 17.47		MYH9_HUMAN (2-631): 8.69e-22: 103: 10.87
+	Hs
		725134 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		MYH10_HUMAN (55-788): 1.22e-26: 119: 10.63
+	Hs
		728465 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		MYH11_HUMAN (2-686): 1.62e-23: 109: 9.77
+	Hs
		724756 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		MYH9_HUMAN (2-631): 8.69e-22: 103: 10.87
+	Hs
		924473 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		MAP1A_HUMAN (212-642): 6.08e-13: 75: 18.04