HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: DDR1 (Q08345)
Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)
Gene: DDR1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.777

Property	Details
Experiments	9659899, 22057045
Identification Methods	pull down, anti bait coimmunoprecipitation
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 913
+	Hs
		666123 SHC1_HUMAN (1-583): 0: 531: 100.00		DDR2_HUMAN (20-905): 0: 843: 51.46
+	Mm
		403430 SHC1_MOUSE (1-583): 0: 527: 94.51		SRC_MOUSE (361-912): 1.24e-128: 399: 23.65
+	Hs
		522805 SHC1_HUMAN (1-583): 0: 531: 100.00		SRC_HUMAN (361-912): 1.28e-125: 391: 23.60
+	Hs
		601467 SHC1_HUMAN (1-583): 0: 531: 100.00		FGFR2_HUMAN (583-905): 4.2e-109: 357: 34.05
+	Hs
		507872 SHC1_HUMAN (1-583): 0: 531: 100.00		FGFR1_HUMAN (540-905): 6.78e-109: 356: 32.52
+	Hs
		607889 SHC1_HUMAN (1-583): 0: 531: 100.00		FGFR4_HUMAN (554-910): 8.48e-107: 350: 33.87
+	Hs
		666119 SHC1_HUMAN (1-583): 0: 531: 100.00		NTRK2_HUMAN (604-906): 1.75e-104: 345: 43.89
+	Mm
		957230 SHC1_MOUSE (1-583): 0: 527: 94.51		NTRK1_MOUSE (604-906): 6.84e-105: 345: 43.23
+	Hs
		433266 SHC1_HUMAN (1-583): 0: 531: 100.00		YES_HUMAN (563-907): 1.25e-105: 339: 31.59
+	Mm
		403451 SHC2_MOUSE (43-582): 6.38e-127: 386: 45.91		SRC_MOUSE (361-912): 1.24e-128: 399: 23.65
+	Hs
		666117 SHC1_HUMAN (1-583): 0: 531: 100.00		NTRK3_HUMAN (607-905): 4.06e-67: 242: 43.63
+	Hs
		384331 SHC1_HUMAN (1-583): 0: 531: 100.00		NTRK1_HUMAN (607-902): 1.43e-66: 240: 45.27
+	Rn
		1129187 SHC1_RAT (111-583): 1.45e-142: 422: 94.72		NTRK2_RAT (604-906): 6.67e-105: 345: 43.89
+	Rn
		728445 SHC1_RAT (111-583): 1.45e-142: 422: 94.72		NTRK1_RAT (604-906): 3.59e-104: 343: 42.90
+	Hs
		1083860 SHC4_HUMAN (7-581): 1.07e-136: 413: 45.53		NTRK2_HUMAN (604-906): 1.75e-104: 345: 43.89
+	Hs
		411312 SHC1_HUMAN (1-583): 0: 531: 100.00		INSR_HUMAN (600-908): 7.71e-53: 202: 37.42
+	Hs
		1083874 SHC3_HUMAN (6-582): 3.32e-127: 387: 45.47		NTRK2_HUMAN (604-906): 1.75e-104: 345: 43.89
+	Hs
		435550 SHC1_HUMAN (1-583): 0: 531: 100.00		IGF1R_HUMAN (600-908): 4.51e-51: 197: 37.22
+	Hs
		385029 SHC4_HUMAN (7-581): 1.07e-136: 413: 45.53		NTRK1_HUMAN (607-902): 1.43e-66: 240: 45.27
+	Hs
		385257 SHC3_HUMAN (6-582): 3.32e-127: 387: 45.47		NTRK1_HUMAN (607-902): 1.43e-66: 240: 45.27