HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: EPS8 (Q12929)
Epidermal growth factor receptor kinase substrate 8
Gene: EPS8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	7791787
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	SH2~SH3_1
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 822
+	Hs
		1020404 GULP1_HUMAN (137-418): 7.16e-48: 171: 19.79		EPS8_HUMAN (1-822): 0: 994: 100.00
+	Hs
		1020367 SHB_HUMAN (369-579): 2.01e-41: 158: 20.63		EPS8_HUMAN (1-822): 0: 994: 100.00
+	Hs
		666037 SHC1_HUMAN (1-583): 0: 531: 100.00		CRKL_HUMAN (487-662): 3.07e-33: 132: 20.79
+	Hs
		433266 SHC1_HUMAN (1-583): 0: 531: 100.00		YES_HUMAN (448-612): 4.43e-29: 124: 16.00
+	Hs
		412038 SHC1_HUMAN (1-583): 0: 531: 100.00		FYN_HUMAN (454-613): 1.08e-27: 120: 16.57
+	Hs
		666036 SHC1_HUMAN (1-583): 0: 531: 100.00		CRK_HUMAN (487-661): 8.43e-28: 116: 18.75
+	Mm
		936445 ANS1B_MOUSE (39-364): 1.02e-45: 175: 17.86		STAM1_MOUSE (458-783): 5.61e-51: 189: 15.11
+	Hs
		548690 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		BTK_HUMAN (422-701): 8.99e-28: 121: 10.77
+	Hs
		411981 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		FYN_HUMAN (454-613): 1.08e-27: 120: 16.57
+	Hs
		548657 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		CRK_HUMAN (487-661): 8.43e-28: 116: 18.75
+	Mm
		1142988 ANS1B_MOUSE (39-364): 1.02e-45: 175: 17.86		PACN1_MOUSE (435-586): 2.47e-27: 118: 17.53
+	Hs
		412098 VAV2_HUMAN (189-579): 1.9e-42: 165: 12.97		FYN_HUMAN (454-613): 1.08e-27: 120: 16.57
+	Hs
		442813 HCK_HUMAN (348-575): 2.72e-43: 164: 17.16		BTK_HUMAN (422-701): 8.99e-28: 121: 10.77
+	Hs
		561384 FER_HUMAN (345-581): 6.27e-42: 163: 18.75		CRK_HUMAN (487-661): 8.43e-28: 116: 18.75
+	Hs
		802608 SHB_HUMAN (369-579): 2.01e-41: 158: 20.63		CRK_HUMAN (487-661): 8.43e-28: 116: 18.75
+	Hs
		208989 NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83		NCK1_HUMAN (536-621): 1.03e-18: 90.8: 30.23
+	Hs
		209098 ANS1B_HUMAN (39-351): 1.55e-45: 175: 17.96		NCK2_HUMAN (535-612): 1.02e-12: 72.7: 24.69
+	Hs
		209141 SHD_HUMAN (328-582): 1.62e-47: 171: 23.02		NCK2_HUMAN (535-612): 1.02e-12: 72.7: 24.69
+	Hs
		208958 NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83		NCK2_HUMAN (535-612): 1.02e-12: 72.7: 24.69
+	Hs
		209059 SHB_HUMAN (369-579): 2.01e-41: 158: 20.63		NCK2_HUMAN (535-612): 1.02e-12: 72.7: 24.69