HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: LCP2 (Q13094)
Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)
Gene: LCP2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	9716598
Identification Methods	affinity chromatography technology, coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH2
Common GO terms	GO:0005829 - cytosol GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 533
+	Hs
		548696 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Mm
		654983 VAV_MOUSE (163-579): 6.29e-54: 198: 11.54		LCP2_MOUSE (1-531): 8.21e-72: 240: 80.98
+	Hs
		209043 NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		442821 HCK_HUMAN (348-575): 2.72e-43: 164: 17.16		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		1024133 SHB_HUMAN (369-579): 2.01e-41: 158: 20.63		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		557674 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		655347 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Mm
		1141384 NCK1_MOUSE (360-575): 1.9e-41: 155: 18.30		LCP2_MOUSE (1-531): 8.21e-72: 240: 80.98
+	Hs
		548737 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28
+	Hs
		1261030 VAV3_HUMAN (190-579): 2.86e-47: 179: 14.52		BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28
+	Hs
		850750 BMX_HUMAN (341-582): 1.11e-38: 153: 19.69		CLNK_HUMAN (182-528): 1.05e-42: 159: 25.00
+	Hs
		655407 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		CLNK_HUMAN (182-528): 1.05e-42: 159: 25.00
+	Hs
		209129 NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83		BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28
+	Gg
		1257382 Q8UUX6_CHICK (190-579): 1.2e-44: 171: 12.84		BLNK_CHICK (52-520): 2.03e-31: 129: 21.42
+	Hs
		557750 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28
+	Hs
		1192751 P55G_HUMAN (473-581): 3.75e-31: 128: 29.20		CLNK_HUMAN (182-528): 1.05e-42: 159: 25.00
+	Hs
		203208 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		SYNJ1_HUMAN (10-466): 1.18e-22: 104: 11.71
+	Hs
		655419 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		TENS4_HUMAN (98-512): 8.78e-21: 98.2: 14.12
+	Hs
		855816 VAV2_HUMAN (189-579): 1.9e-42: 165: 12.97		TITIN_HUMAN (174-447): 1.53e-11: 69.6: 10.64
+	Hs
		655524 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		MYO16_HUMAN (111-438): 6.65e-11: 67.4: 12.90