HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: GRAP (Q13588)
GRB2-related adapter protein
Gene: GRAP

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	8995379
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~SH3_1
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005154 - epidermal growth factor receptor binding GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 217
+	Hs
		666057 SHC1_HUMAN (1-583): 0: 531: 100.00		GRB2_HUMAN (1-216): 4.15e-69: 212: 59.72
+	Mm
		957235 SHC1_MOUSE (1-583): 0: 527: 94.51		GRB2_MOUSE (1-216): 3.23e-69: 212: 59.72
+	Hs
		337362 SHC1_HUMAN (1-583): 0: 531: 100.00		ABL1_HUMAN (3-180): 4.01e-52: 182: 31.69
+	Hs
		69203 SHC1_HUMAN (1-583): 0: 531: 100.00		A9UF07_HUMAN (3-180): 2.07e-51: 180: 31.69
+	Hs
		433266 SHC1_HUMAN (1-583): 0: 531: 100.00		YES_HUMAN (3-217): 1.29e-37: 138: 24.05
+	Hs
		433604 SHC1_HUMAN (1-583): 0: 531: 100.00		LYN_HUMAN (4-204): 4.34e-36: 134: 25.58
+	Rn
		924995 SHC1_RAT (111-583): 1.45e-142: 422: 94.72		GRB2_RAT (1-216): 4.15e-69: 212: 59.72
+	Hs
		666033 SHC1_HUMAN (1-583): 0: 531: 100.00		ABL2_HUMAN (4-137): 3.81e-23: 98.6: 38.13
+	Hs
		666029 SHC1_HUMAN (1-583): 0: 531: 100.00		CSK_HUMAN (2-137): 1.78e-22: 96.3: 35.37
+	Hs
		924646 SHC4_HUMAN (7-581): 1.07e-136: 413: 45.53		GRB2_HUMAN (1-216): 4.15e-69: 212: 59.72
+	Hs
		412038 SHC1_HUMAN (1-583): 0: 531: 100.00		FYN_HUMAN (154-215): 1.46e-12: 67.7: 31.25
+	Hs
		666186 SHC1_HUMAN (1-583): 0: 531: 100.00		VAV3_HUMAN (3-57): 2.87e-12: 67.1: 30.91
+	Hs
		522805 SHC1_HUMAN (1-583): 0: 531: 100.00		SRC_HUMAN (141-214): 3.55e-11: 63.8: 21.05
+	Mm
		292683 SHC1_MOUSE (1-583): 0: 527: 94.51		GRAP2_MOUSE (3-55): 8.89e-12: 65.2: 33.96
+	Mm
		403430 SHC1_MOUSE (1-583): 0: 527: 94.51		SRC_MOUSE (75-214): 2.28e-11: 64.2: 14.09
+	Hs
		924476 SHC2_HUMAN (56-582): 4.56e-116: 358: 44.88		GRB2_HUMAN (1-216): 4.15e-69: 212: 59.72
+	Dm
		993194 Q9V3C8_DROME (128-581): 3.26e-84: 270: 36.56		GRAP_DROME (1-216): 2.57e-58: 184: 53.24
+	Mm
		403451 SHC2_MOUSE (43-582): 6.38e-127: 386: 45.91		SRC_MOUSE (75-214): 2.28e-11: 64.2: 14.09
+	Hs
		855787 SHC2_HUMAN (56-582): 4.56e-116: 358: 44.88		VAV2_HUMAN (3-56): 5.17e-12: 66.1: 34.55
+	Mm
		403440 SHC3_MOUSE (128-582): 1.14e-111: 343: 53.26		SRC_MOUSE (75-214): 2.28e-11: 64.2: 14.09