HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: RPGF1 (Q13905)
Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G)
Gene: RAPGEF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	9344843
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 1077
+	Hs
		442826 HCK_HUMAN (348-575): 2.72e-43: 164: 17.16		RPGF1_HUMAN (1-1077): 0: 1636: 100.00
+	Hs
		557683 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		RPGF1_HUMAN (1-1077): 0: 1636: 100.00
+	Hs
		655361 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		RPGF1_HUMAN (1-1077): 0: 1636: 100.00
+	Hs
		924558 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		RPGF1_HUMAN (1-1077): 0: 1636: 100.00
+	Hs
		666086 SHC1_HUMAN (1-583): 0: 531: 100.00		SOS2_HUMAN (664-1077): 4.44e-112: 380: 25.22
+	Mm
		957237 SHC1_MOUSE (1-583): 0: 527: 94.51		SOS1_MOUSE (662-1077): 1.49e-111: 378: 23.18
+	Hs
		666085 SHC1_HUMAN (1-583): 0: 531: 100.00		SOS1_HUMAN (662-1077): 9.7e-110: 373: 23.39
+	Rn
		88906 SHC1_RAT (111-583): 1.45e-142: 422: 94.72		D4A3T0_RAT (662-1077): 3.74e-110: 374: 23.18
+	Hs
		209038 NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83		SOS1_HUMAN (662-1077): 9.7e-110: 373: 23.39
+	Hs
		442816 HCK_HUMAN (348-575): 2.72e-43: 164: 17.16		SOS1_HUMAN (662-1077): 9.7e-110: 373: 23.39
+	Hs
		557669 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		SOS2_HUMAN (664-1077): 4.44e-112: 380: 25.22
+	Hs
		655333 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		SOS2_HUMAN (664-1077): 4.44e-112: 380: 25.22
+	Hs
		557668 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		SOS1_HUMAN (662-1077): 9.7e-110: 373: 23.39
+	Hs
		655332 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		SOS1_HUMAN (662-1077): 9.7e-110: 373: 23.39
+	Dm
		644374 SRC42_DROME (351-579): 6.25e-40: 154: 18.07		SOS_DROME (683-1076): 1.39e-104: 362: 24.22
+	Hs
		924512 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		SOS2_HUMAN (664-1077): 4.44e-112: 380: 25.22
+	Hs
		924511 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		SOS1_HUMAN (662-1077): 9.7e-110: 373: 23.39
+	Hs
		557756 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		RPGF5_HUMAN (712-1064): 1.95e-87: 295: 24.11
+	Hs
		557709 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		RGPS1_HUMAN (834-1075): 2.18e-70: 247: 29.73
+	Hs
		924619 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		RGPS1_HUMAN (834-1075): 2.18e-70: 247: 29.73