HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: ERBB4 (Q15303)
Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
Gene: ERBB4

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.83 1.00 0.916

The method score is based on:

Property Details
Experiments 16729043, 22973453, 9019162, 16273093, 24658140
Identification Methods affinity chromatography technology, pull down, unspecified method, protein array, ubiquitin reconstruction
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~SH2
Common GO terms GO:0005154 - epidermal growth factor receptor binding
GO:0005759 - mitochondrial matrix
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007507 - heart development
and 4 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 583
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024