HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: NTRK3 (Q16288)
NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)
Gene: NTRK3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	10092678, 35384245
Identification Methods	pull down, affinity chromatography technology, proximity labelling technology
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	LRR_8~SH2, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0007507 - heart development GO:0008284 - positive regulation of cell population proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 839
+	Hs
		666119 SHC1_HUMAN (1-583): 0: 531: 100.00		NTRK2_HUMAN (6-839): 0: 557: 52.87
+	Hs
		384331 SHC1_HUMAN (1-583): 0: 531: 100.00		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Mm
		957230 SHC1_MOUSE (1-583): 0: 527: 94.51		NTRK1_MOUSE (14-839): 1.55e-173: 522: 45.88
+	Hs
		601467 SHC1_HUMAN (1-583): 0: 531: 100.00		FGFR2_HUMAN (203-838): 1.97e-168: 510: 24.89
+	Hs
		507872 SHC1_HUMAN (1-583): 0: 531: 100.00		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		607889 SHC1_HUMAN (1-583): 0: 531: 100.00		FGFR4_HUMAN (166-837): 6.43e-152: 466: 24.57
+	Rn
		1129187 SHC1_RAT (111-583): 1.45e-142: 422: 94.72		NTRK2_RAT (6-839): 0: 557: 52.88
+	Hs
		1083860 SHC4_HUMAN (7-581): 1.07e-136: 413: 45.53		NTRK2_HUMAN (6-839): 0: 557: 52.87
+	Hs
		1083874 SHC3_HUMAN (6-582): 3.32e-127: 387: 45.47		NTRK2_HUMAN (6-839): 0: 557: 52.87
+	Rn
		728445 SHC1_RAT (111-583): 1.45e-142: 422: 94.72		NTRK1_RAT (58-839): 1.52e-171: 517: 47.78
+	Hs
		385029 SHC4_HUMAN (7-581): 1.07e-136: 413: 45.53		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		385257 SHC3_HUMAN (6-582): 3.32e-127: 387: 45.47		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		434141 SHC1_HUMAN (1-583): 0: 531: 100.00		RET_HUMAN (282-837): 1.5e-108: 360: 25.76
+	Hs
		666123 SHC1_HUMAN (1-583): 0: 531: 100.00		DDR2_HUMAN (527-824): 2.05e-70: 250: 43.30
+	Hs
		666088 SHC1_HUMAN (1-583): 0: 531: 100.00		DDR1_HUMAN (535-824): 9.4e-68: 244: 43.63
+	Hs
		434220 SHC4_HUMAN (7-581): 1.07e-136: 413: 45.53		RET_HUMAN (282-837): 1.5e-108: 360: 25.76
+	Hs
		411312 SHC1_HUMAN (1-583): 0: 531: 100.00		INSR_HUMAN (513-824): 1.34e-64: 238: 39.43
+	Hs
		435550 SHC1_HUMAN (1-583): 0: 531: 100.00		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Hs
		666189 SHC1_HUMAN (1-583): 0: 531: 100.00		ALK_HUMAN (513-816): 2.78e-59: 222: 39.03
+	Mm
		956924 SHC1_MOUSE (1-583): 0: 527: 94.51		ALK_MOUSE (513-816): 6.14e-60: 224: 39.36