HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: NTRK2 (Q16620)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Gene: NTRK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.834

Property	Details
Experiments	28213521, 10092678, 26253177
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	LRR_8~SH2, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0008284 - positive regulation of cell population proliferation GO:0043410 - positive regulation of MAPK cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 822
+	Hs
		666117 SHC1_HUMAN (1-583): 0: 531: 100.00		NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84
+	Hs
		607889 SHC1_HUMAN (1-583): 0: 531: 100.00		FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68
+	Hs
		1083860 SHC4_HUMAN (7-581): 1.07e-136: 413: 45.53		NTRK2_HUMAN (1-822): 0: 638: 100.00
+	Mm
		957230 SHC1_MOUSE (1-583): 0: 527: 94.51		NTRK1_MOUSE (45-822): 2.04e-173: 521: 47.09
+	Rn
		1129187 SHC1_RAT (111-583): 1.45e-142: 422: 94.72		NTRK2_RAT (1-822): 0: 622: 93.55
+	Hs
		384331 SHC1_HUMAN (1-583): 0: 531: 100.00		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		507872 SHC1_HUMAN (1-583): 0: 531: 100.00		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		601467 SHC1_HUMAN (1-583): 0: 531: 100.00		FGFR2_HUMAN (120-821): 4.81e-164: 498: 23.04
+	Hs
		665145 SHC1_HUMAN (1-583): 0: 531: 100.00		EPHA2_HUMAN (148-822): 4.29e-141: 443: 22.43
+	Rn
		728445 SHC1_RAT (111-583): 1.45e-142: 422: 94.72		NTRK1_RAT (45-822): 7.98e-173: 520: 47.85
+	Hs
		385029 SHC4_HUMAN (7-581): 1.07e-136: 413: 45.53		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		434141 SHC1_HUMAN (1-583): 0: 531: 100.00		RET_HUMAN (436-820): 1.09e-115: 379: 33.00
+	Hs
		666088 SHC1_HUMAN (1-583): 0: 531: 100.00		DDR1_HUMAN (535-807): 1.28e-74: 263: 47.37
+	Hs
		666123 SHC1_HUMAN (1-583): 0: 531: 100.00		DDR2_HUMAN (491-807): 5.97e-75: 263: 43.40
+	Hs
		434220 SHC4_HUMAN (7-581): 1.07e-136: 413: 45.53		RET_HUMAN (436-820): 1.09e-115: 379: 33.00
+	Hs
		435550 SHC1_HUMAN (1-583): 0: 531: 100.00		IGF1R_HUMAN (513-797): 1.01e-70: 256: 43.95
+	Hs
		411312 SHC1_HUMAN (1-583): 0: 531: 100.00		INSR_HUMAN (513-809): 2.11e-70: 254: 43.38
+	Hs
		666189 SHC1_HUMAN (1-583): 0: 531: 100.00		ALK_HUMAN (513-799): 4.96e-64: 236: 41.44
+	Mm
		956924 SHC1_MOUSE (1-583): 0: 527: 94.51		ALK_MOUSE (513-799): 4.49e-65: 239: 42.12
+	Hs
		666003 SHC1_HUMAN (1-583): 0: 531: 100.00		LTK_HUMAN (506-808): 6.29e-61: 223: 38.07