HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: DDR2 (Q16832)
Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b)
Gene: DDR2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	1.00	0.821

Property	Details
Experiments	11884411, 35384245
Identification Methods	two hybrid, affinity chromatography technology, coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 855
+	Hs
		666088 SHC1_HUMAN (1-583): 0: 531: 100.00		DDR1_HUMAN (22-849): 0: 655: 52.08
+	Hs
		666119 SHC1_HUMAN (1-583): 0: 531: 100.00		NTRK2_HUMAN (498-850): 2.17e-106: 348: 40.50
+	Hs
		507872 SHC1_HUMAN (1-583): 0: 531: 100.00		FGFR1_HUMAN (505-851): 2.72e-102: 337: 32.49
+	Hs
		601467 SHC1_HUMAN (1-583): 0: 531: 100.00		FGFR2_HUMAN (522-851): 6.41e-102: 336: 34.42
+	Mm
		957230 SHC1_MOUSE (1-583): 0: 527: 94.51		NTRK1_MOUSE (551-850): 3.18e-103: 339: 43.28
+	Hs
		384331 SHC1_HUMAN (1-583): 0: 531: 100.00		NTRK1_HUMAN (551-850): 5.06e-101: 333: 42.62
+	Hs
		666117 SHC1_HUMAN (1-583): 0: 531: 100.00		NTRK3_HUMAN (551-849): 3.61e-99: 329: 42.63
+	Hs
		607889 SHC1_HUMAN (1-583): 0: 531: 100.00		FGFR4_HUMAN (537-849): 4.35e-98: 325: 34.78
+	Hs
		412038 SHC1_HUMAN (1-583): 0: 531: 100.00		FYN_HUMAN (548-850): 3.85e-99: 320: 35.64
+	Hs
		433266 SHC1_HUMAN (1-583): 0: 531: 100.00		YES_HUMAN (556-850): 2.32e-97: 316: 34.58
+	Hs
		522805 SHC1_HUMAN (1-583): 0: 531: 100.00		SRC_HUMAN (521-850): 1.38e-97: 316: 31.52
+	Rn
		1129187 SHC1_RAT (111-583): 1.45e-142: 422: 94.72		NTRK2_RAT (498-850): 9.51e-107: 349: 40.50
+	Hs
		1083860 SHC4_HUMAN (7-581): 1.07e-136: 413: 45.53		NTRK2_HUMAN (498-850): 2.17e-106: 348: 40.50
+	Rn
		728445 SHC1_RAT (111-583): 1.45e-142: 422: 94.72		NTRK1_RAT (551-850): 7.16e-103: 338: 42.95
+	Hs
		435550 SHC1_HUMAN (1-583): 0: 531: 100.00		IGF1R_HUMAN (535-845): 9.34e-58: 217: 40.13
+	Hs
		385029 SHC4_HUMAN (7-581): 1.07e-136: 413: 45.53		NTRK1_HUMAN (551-850): 5.06e-101: 333: 42.62
+	Hs
		411312 SHC1_HUMAN (1-583): 0: 531: 100.00		INSR_HUMAN (511-849): 1.55e-55: 210: 37.76
+	Hs
		337362 SHC1_HUMAN (1-583): 0: 531: 100.00		ABL1_HUMAN (557-846): 9.71e-55: 207: 41.03
+	Hs
		69203 SHC1_HUMAN (1-583): 0: 531: 100.00		A9UF07_HUMAN (557-846): 4.25e-54: 206: 41.03
+	Hs
		385257 SHC3_HUMAN (6-582): 3.32e-127: 387: 45.47		NTRK1_HUMAN (551-850): 5.06e-101: 333: 42.62