HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: M4K3 (Q8IVH8)
Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3)
Gene: MAP4K3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	32640226
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 894
+	Hs
		666200 SHC1_HUMAN (1-583): 0: 531: 100.00		M4K5_HUMAN (1-894): 0: 940: 65.41
+	Hs
		557731 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		M4K3_HUMAN (1-894): 0: 1060: 100.00
+	Hs
		442897 HCK_HUMAN (348-575): 2.72e-43: 164: 17.16		M4K5_HUMAN (1-894): 0: 940: 65.41
+	Hs
		557840 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		M4K5_HUMAN (1-894): 0: 940: 65.41
+	Hs
		209135 NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83		M4K1_HUMAN (6-893): 0: 782: 39.19
+	Hs
		557762 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		M4K1_HUMAN (6-893): 0: 782: 39.19
+	Hs
		655434 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		M4K1_HUMAN (6-893): 0: 782: 39.19
+	Hs
		1054045 GRB14_HUMAN (66-579): 1.66e-73: 246: 14.41		STK26_HUMAN (3-291): 7.94e-118: 366: 46.05
+	Mm
		643056 P85A_MOUSE (300-581): 6.66e-38: 151: 15.99		AKT1_MOUSE (6-341): 3.93e-134: 411: 23.41
+	Hs
		655233 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		AKT1_HUMAN (6-341): 6.7e-134: 410: 23.70
+	Hs
		616675 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		KS6B1_HUMAN (8-440): 7.76e-129: 399: 21.57
+	Hs
		855832 VAV2_HUMAN (189-579): 1.9e-42: 165: 12.97		STK24_HUMAN (9-291): 7.65e-116: 362: 46.67
+	Hs
		655378 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		KS6A2_HUMAN (14-326): 2.08e-97: 323: 23.44
+	Hs
		209186 NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83		TNIK_HUMAN (6-290): 6.53e-73: 264: 48.32
+	Hs
		209112 NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83		MINK1_HUMAN (6-290): 1.01e-69: 254: 47.14
+	Hs
		557820 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		TNIK_HUMAN (6-290): 6.53e-73: 264: 48.32
+	Ce
		1095301 Q95PW9_CAEEL (392-581): 3.88e-36: 141: 20.41		MIG15_CAEEL (8-360): 1.61e-75: 270: 40.91
+	Hs
		208968 NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83		M4K4_HUMAN (8-290): 6.77e-67: 245: 47.28
+	Hs
		557740 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		MINK1_HUMAN (6-290): 1.01e-69: 254: 47.14
+	Hs
		324734 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		M4K4_HUMAN (8-290): 6.77e-67: 245: 47.28