HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: RIN3 (Q8TB24)
Ras and Rab interactor 3 (Ras interaction/interference protein 3)
Gene: RIN3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	32552912
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 985
+	Hs
		1251876 ANS1A_HUMAN (40-393): 2.28e-42: 165: 18.41		RIN3_HUMAN (1-985): 1.3e-180: 552: 100.00
+	Hs
		557745 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		RIN3_HUMAN (1-985): 1.3e-180: 552: 100.00
+	Hs
		70370 B2R6S4_HUMAN (360-575): 1.55e-41: 155: 18.30		RIN3_HUMAN (1-985): 1.3e-180: 552: 100.00
+	Hs
		69536 B0LPF3_HUMAN (482-578): 1.65e-15: 77.5: 30.48		RIN3_HUMAN (1-985): 1.3e-180: 552: 100.00
+	Hs
		924717 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		RIN3_HUMAN (1-985): 1.3e-180: 552: 100.00
+	Hs
		957126 SHC2_HUMAN (56-582): 4.56e-116: 358: 44.88		Q6NSK7_HUMAN (1-497): 1.57e-56: 213: 65.19
+	Hs
		855796 VAV2_HUMAN (189-579): 1.9e-42: 165: 12.97		GAPD1_HUMAN (23-841): 7.61e-57: 216: 14.42
+	Hs
		557717 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		Q6NSK7_HUMAN (1-497): 1.57e-56: 213: 65.19
+	Hs
		166030 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		SYNJ2_HUMAN (181-524): 2.35e-51: 199: 19.77
+	Hs
		166032 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		SYNJ2_HUMAN (181-524): 2.35e-51: 199: 19.77
+	Hs
		1191809 ANS1B_HUMAN (39-351): 1.55e-45: 175: 17.96		RIN2_HUMAN (28-376): 3.27e-39: 159: 28.49
+	Hs
		1044774 Q49AR9_HUMAN (40-425): 1.96e-47: 176: 18.14		RIN1_HUMAN (6-327): 3.07e-21: 101: 26.32
+	Hs
		166042 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		SYNJ2_HUMAN (181-524): 2.35e-51: 199: 19.77
+	Hs
		1044783 ANS1B_HUMAN (39-351): 1.55e-45: 175: 17.96		RIN1_HUMAN (6-327): 3.07e-21: 101: 26.32
+	Hs
		1044796 ANS1A_HUMAN (40-393): 2.28e-42: 165: 18.41		RIN1_HUMAN (6-327): 3.07e-21: 101: 26.32
+	Hs
		1044790 SH2D3_HUMAN (333-582): 8.25e-40: 157: 23.55		RIN1_HUMAN (6-327): 3.07e-21: 101: 26.32
+	Hs
		1044765 GRB7_HUMAN (371-563): 3.91e-33: 135: 21.57		RIN1_HUMAN (6-327): 3.07e-21: 101: 26.32
+	Hs
		203208 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		SYNJ1_HUMAN (311-736): 7.31e-12: 71.8: 11.24
+	Hs
		203218 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		SYNJ1_HUMAN (311-736): 7.31e-12: 71.8: 11.24
+	Hs
		554292 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		MUC1_HUMAN (250-732): 1.28e-10: 67.9: 10.43