HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: UBS3B (Q8TF42)
Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2)
Gene: UBASH3B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.50	0.606

Property	Details
Experiments	24189400, 28690151, 19380743
Identification Methods	affinity chromatography technology, unspecified method, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 649
+	Hs
		666057 SHC1_HUMAN (1-583): 0: 531: 100.00		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Mm
		957235 SHC1_MOUSE (1-583): 0: 527: 94.51		GRB2_MOUSE (156-319): 3.38e-45: 161: 21.56
+	Hs
		666104 SHC1_HUMAN (1-583): 0: 531: 100.00		GRAP_HUMAN (156-317): 1.29e-24: 104: 19.16
+	Rn
		924995 SHC1_RAT (111-583): 1.45e-142: 422: 94.72		GRB2_RAT (156-319): 1.37e-45: 163: 21.56
+	Hs
		924646 SHC4_HUMAN (7-581): 1.07e-136: 413: 45.53		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Hs
		924476 SHC2_HUMAN (56-582): 4.56e-116: 358: 44.88		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Dm
		993194 Q9V3C8_DROME (128-581): 3.26e-84: 270: 36.56		GRAP_DROME (152-316): 3.13e-22: 97.2: 18.07
+	Hs
		548677 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Hs
		924777 Q96D37_HUMAN (163-578): 1.11e-54: 200: 12.25		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Mm
		654982 VAV_MOUSE (163-579): 6.29e-54: 198: 11.54		GRB2_MOUSE (156-319): 3.38e-45: 161: 21.56
+	Hs
		924938 VAV3_HUMAN (190-579): 2.86e-47: 179: 14.52		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Hs
		855781 VAV2_HUMAN (189-579): 1.9e-42: 165: 12.97		GRB2_HUMAN (156-319): 1.37e-45: 163: 21.56
+	Hs
		1115812 Q49AR9_HUMAN (40-425): 1.96e-47: 176: 18.14		SH3K1_HUMAN (221-375): 5.02e-29: 124: 25.00
+	Hs
		1268487 ANS1A_HUMAN (40-393): 2.28e-42: 165: 18.41		SH3K1_HUMAN (221-375): 5.02e-29: 124: 25.00
+	Hs
		235513 Q49AR9_HUMAN (40-425): 1.96e-47: 176: 18.14		VINEX_HUMAN (229-317): 1e-22: 104: 26.97
+	Hs
		208967 NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83		SRBS2_HUMAN (230-317): 1.4e-22: 105: 27.84
+	Hs
		235561 ANS1A_HUMAN (40-393): 2.28e-42: 165: 18.41		VINEX_HUMAN (229-317): 1e-22: 104: 26.97
+	Hs
		209154 NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83		SRBS1_HUMAN (258-317): 1.89e-18: 92.2: 40.00
+	Hs
		1059985 Q49AR9_HUMAN (40-425): 1.96e-47: 176: 18.14		LASP1_HUMAN (254-315): 1.29e-12: 70.2: 30.65
+	Hs
		1060023 ANS1A_HUMAN (40-393): 2.28e-42: 165: 18.41		LASP1_HUMAN (254-315): 1.29e-12: 70.2: 30.65