HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: CSF3R (Q99062)
Granulocyte colony-stimulating factor receptor (G-CSF receptor) (G-CSF-R) (CD antigen CD114)
Gene: CSF3R

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	14557262, 9824671, 17001306
Identification Methods	pull down, unspecified method, affinity chromatography technology, far western blotting, protein complementation assay
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~fn3
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 836
+	Mm
		770715 SHC1_MOUSE (1-583): 0: 527: 94.51		CSF3R_MOUSE (1-836): 1.78e-153: 472: 60.29
+	Hs
		666027 SHC1_HUMAN (1-583): 0: 531: 100.00		IL6RB_HUMAN (8-802): 1.15e-97: 327: 23.48
+	Hs
		442875 HCK_HUMAN (348-575): 2.72e-43: 164: 17.16		CSF3R_HUMAN (1-836): 2.01e-167: 508: 100.00
+	Mm
		435879 HCK_MOUSE (348-582): 2.92e-40: 155: 19.11		CSF3R_MOUSE (1-836): 1.78e-153: 472: 60.29
+	Hs
		924809 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		CSF3R_HUMAN (1-836): 2.01e-167: 508: 100.00
+	Mm
		770716 GRB2_MOUSE (482-578): 3.54e-15: 76.8: 30.48		CSF3R_MOUSE (1-836): 1.78e-153: 472: 60.29
+	Hs
		548653 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		IL6RB_HUMAN (8-802): 1.15e-97: 327: 23.48
+	Hs
		442787 HCK_HUMAN (348-575): 2.72e-43: 164: 17.16		IL6RB_HUMAN (8-802): 1.15e-97: 327: 23.48
+	Hs
		655246 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		IL6RB_HUMAN (8-802): 1.15e-97: 327: 23.48
+	Mm
		936320 ANS1B_MOUSE (39-364): 1.02e-45: 175: 17.86		DCC_MOUSE (14-825): 5.99e-64: 236: 11.19
+	Hs
		770194 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		IL6RB_HUMAN (8-802): 1.15e-97: 327: 23.48
+	Hs
		557632 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		DCC_HUMAN (14-825): 1.07e-64: 238: 11.15
+	Hs
		548629 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		PRLR_HUMAN (121-341): 1.45e-46: 178: 24.14
+	Mm
		69652 ANS1B_MOUSE (39-364): 1.02e-45: 175: 17.86		PTPRS_MOUSE (19-772): 5.49e-47: 184: 12.11
+	Hs
		616962 BMX_HUMAN (341-582): 1.11e-38: 153: 19.69		PTPRD_HUMAN (19-784): 1.83e-50: 195: 13.96
+	Hs
		560471 VAV2_HUMAN (189-579): 1.9e-42: 165: 12.97		PRLR_HUMAN (121-341): 1.45e-46: 178: 24.14
+	Hs
		489988 SH2D3_HUMAN (333-582): 8.25e-40: 157: 23.55		PTPRF_HUMAN (3-547): 3.25e-41: 166: 11.65
+	Mm
		524116 ANS1B_MOUSE (39-364): 1.02e-45: 175: 17.86		CNTN1_MOUSE (23-827): 8.09e-34: 142: 9.98
+	Hs
		855816 VAV2_HUMAN (189-579): 1.9e-42: 165: 12.97		TITIN_HUMAN (97-446): 1.33e-09: 64.3: 8.18
+	Hs
		817315 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		LEPR_HUMAN (83-329): 2.37e-13: 76.4: 15.94