HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	11888936, 33961781, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 1620
+	Mm
		956924 SHC1_MOUSE (1-583): 0: 527: 94.51		ALK_MOUSE (1-1620): 0: 1775: 87.07
+	Hs
		666003 SHC1_HUMAN (1-583): 0: 531: 100.00		LTK_HUMAN (606-1458): 6.35e-175: 550: 53.24
+	Hs
		434141 SHC1_HUMAN (1-583): 0: 531: 100.00		RET_HUMAN (842-1477): 4.8e-137: 455: 23.56
+	Hs
		666116 SHC1_HUMAN (1-583): 0: 531: 100.00		ERBB4_HUMAN (882-1547): 2.9e-122: 418: 22.24
+	Hs
		601467 SHC1_HUMAN (1-583): 0: 531: 100.00		FGFR2_HUMAN (952-1433): 9.52e-123: 407: 25.24
+	Hs
		666033 SHC1_HUMAN (1-583): 0: 531: 100.00		ABL2_HUMAN (1103-1526): 1.55e-118: 405: 32.47
+	Hs
		507872 SHC1_HUMAN (1-583): 0: 531: 100.00		FGFR1_HUMAN (952-1454): 2.04e-118: 395: 26.06
+	Hs
		666073 SHC1_HUMAN (1-583): 0: 531: 100.00		TIE2_HUMAN (954-1389): 7.66e-115: 393: 29.30
+	Hs
		411312 SHC1_HUMAN (1-583): 0: 531: 100.00		INSR_HUMAN (973-1436): 1.01e-112: 392: 34.25
+	Hs
		435550 SHC1_HUMAN (1-583): 0: 531: 100.00		IGF1R_HUMAN (1037-1385): 8.86e-111: 386: 39.77
+	Hs
		666110 SHC1_HUMAN (1-583): 0: 531: 100.00		FAK2_HUMAN (1054-1518): 4.66e-109: 374: 27.45
+	Hs
		434220 SHC4_HUMAN (7-581): 1.07e-136: 413: 45.53		RET_HUMAN (842-1477): 4.8e-137: 455: 23.56
+	Hs
		666119 SHC1_HUMAN (1-583): 0: 531: 100.00		NTRK2_HUMAN (1093-1375): 7.35e-64: 236: 41.44
+	Mm
		957230 SHC1_MOUSE (1-583): 0: 527: 94.51		NTRK1_MOUSE (1111-1390): 1.48e-63: 235: 42.71
+	Hs
		384331 SHC1_HUMAN (1-583): 0: 531: 100.00		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		666117 SHC1_HUMAN (1-583): 0: 531: 100.00		NTRK3_HUMAN (1093-1375): 2.69e-59: 223: 39.03
+	Mm
		957226 SHC1_MOUSE (1-583): 0: 527: 94.51		UFO_MOUSE (1039-1393): 3.29e-55: 211: 35.60
+	Rn
		1129187 SHC1_RAT (111-583): 1.45e-142: 422: 94.72		NTRK2_RAT (1093-1375): 8.02e-64: 236: 41.44
+	Rn
		728445 SHC1_RAT (111-583): 1.45e-142: 422: 94.72		NTRK1_RAT (1111-1390): 1.4e-63: 235: 42.71
+	Hs
		385029 SHC4_HUMAN (7-581): 1.07e-136: 413: 45.53		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07