HitPredict

Interactor 1: SEM5 (P29355)
Sex muscle abnormal protein 5
Gene: sem-5

Interactor 2: DYN1 (P39055)
Dynamin (EC 3.6.5.5)
Gene: dyn-1

Species: Caenorhabditis elegans

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	23549480
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 228 Ce			1 830
+	Mm
		1141147 GRB2_MOUSE (1-214): 3.67e-66: 205: 57.60		DYN3_MOUSE (5-830): 0: 1001: 63.76
+	Mm
		760450 GRB2_MOUSE (1-214): 3.67e-66: 205: 57.60		DYN1_MOUSE (5-826): 0: 995: 62.05
+	Hs
		924499 GRB2_HUMAN (1-214): 5.56e-66: 204: 57.60		DYN1_HUMAN (5-820): 0: 996: 62.07
+	Rn
		599402 GRB2_RAT (1-214): 5.56e-66: 204: 57.60		DYN1_RAT (5-820): 0: 991: 62.31
+	Mm
		760474 GRB2_MOUSE (1-214): 3.67e-66: 205: 57.60		DYN2_MOUSE (5-830): 0: 986: 63.59
+	Hs
		924956 GRB2_HUMAN (1-214): 5.56e-66: 204: 57.60		DYN3_HUMAN (5-830): 0: 987: 62.43
+	Hs
		840663 GRB2_HUMAN (1-214): 5.56e-66: 204: 57.60		DYN2_HUMAN (5-830): 0: 982: 63.05
+	Dm
		649302 GRAP_DROME (1-213): 3.63e-60: 189: 61.03		DYN_DROME (8-830): 0: 949: 65.58
+	Hs
		840878 CD2AP_HUMAN (1-221): 1.54e-33: 128: 17.20		DYN2_HUMAN (5-830): 0: 982: 63.05
+	Hs
		337437 ABL1_HUMAN (4-140): 3.2e-24: 102: 38.73		DYN1_HUMAN (5-820): 0: 996: 62.07
+	Hs
		337597 ABL1_HUMAN (4-140): 3.2e-24: 102: 38.73		DYN3_HUMAN (5-830): 0: 987: 62.43
+	Hs
		337399 ABL1_HUMAN (4-140): 3.2e-24: 102: 38.73		DYN2_HUMAN (5-830): 0: 982: 63.05
+	Mm
		760469 ITSN1_MOUSE (53-222): 2.31e-16: 79.6: 15.61		DYN1_MOUSE (5-826): 0: 995: 62.05
+	Ce
		760500 VAV_CAEEL (55-212): 1.6e-19: 88.6: 33.93		DYN1_CAEEL (1-762): 0: 986: 100.00
+	Hs
		412411 FYN_HUMAN (159-228): 3.6e-18: 84.6: 25.00		DYN3_HUMAN (5-830): 0: 987: 62.43
+	Ce
		220206 SRC2_CAEEL (114-228): 2.45e-17: 81.9: 21.37		DYN1_CAEEL (1-762): 0: 986: 100.00
+	Hs
		412090 FYN_HUMAN (159-228): 3.6e-18: 84.6: 25.00		DYN2_HUMAN (5-830): 0: 982: 63.05
+	Mm
		760488 ITSN1_MOUSE (53-222): 2.31e-16: 79.6: 15.61		DYN2_MOUSE (5-830): 0: 986: 63.59
+	Hs
		840840 ITSN2_HUMAN (121-222): 1.75e-16: 80: 21.15		DYN2_HUMAN (5-830): 0: 982: 63.05
+	Hs
		522862 SRC_HUMAN (57-226): 3.34e-16: 78.9: 16.28		DYN2_HUMAN (5-830): 0: 982: 63.05