HitPredict

Interactor 1: SEM5 (P29355)
Sex muscle abnormal protein 5
Gene: sem-5

Interactor 2: Q6ABG8 (Q6ABG8)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27)
Gene: sli-1

Species: Caenorhabditis elegans

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.639

Property	Details
Experiments	10615043, 12679813, 14704431
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 228 Ce			1 523
+	Ce
		666213 SEM5_CAEEL (1-228): 9.03e-71: 217: 100.00		Q19019_CAEEL (1-523): 0: 877: 89.86
+	Mm
		1112053 GRB2_MOUSE (1-214): 3.67e-66: 205: 57.60		CBLB_MOUSE (47-509): 0: 783: 49.58
+	Mm
		610598 GRB2_MOUSE (1-214): 3.67e-66: 205: 57.60		CBL_MOUSE (48-518): 0: 782: 47.69
+	Mm
		82735 GRB2_MOUSE (1-214): 3.67e-66: 205: 57.60		B9EKI5_MOUSE (47-509): 0: 782: 49.58
+	Hs
		924539 GRB2_HUMAN (1-214): 5.56e-66: 204: 57.60		CBLB_HUMAN (47-509): 0: 780: 49.79
+	Rn
		88774 GRB2_RAT (1-214): 5.56e-66: 204: 57.60		D3ZV15_RAT (48-518): 0: 778: 47.69
+	Hs
		610338 GRB2_HUMAN (1-214): 5.56e-66: 204: 57.60		CBL_HUMAN (48-518): 0: 776: 47.69
+	Hs
		610437 Q6ICN0_HUMAN (1-214): 1.42e-65: 204: 57.14		CBL_HUMAN (48-518): 0: 776: 47.69
+	Hs
		610303 BLK_HUMAN (3-178): 2.01e-55: 185: 26.88		CBL_HUMAN (48-518): 0: 776: 47.69
+	Hs
		1027634 CD2AP_HUMAN (1-221): 1.54e-33: 128: 17.20		CBLB_HUMAN (47-509): 0: 780: 49.79
+	Hs
		610540 CD2AP_HUMAN (1-221): 1.54e-33: 128: 17.20		CBL_HUMAN (48-518): 0: 776: 47.69
+	Dm
		220607 GRAP_DROME (1-213): 3.63e-60: 189: 61.03		O46034_DROME (47-448): 0: 699: 54.90
+	Mm
		337618 ABL1_MOUSE (4-140): 3.29e-24: 102: 38.73		CBL_MOUSE (48-518): 0: 782: 47.69
+	Hs
		337458 ABL1_HUMAN (4-140): 3.2e-24: 102: 38.73		CBLB_HUMAN (47-509): 0: 780: 49.79
+	Hs
		69208 A9UF07_HUMAN (4-140): 6.95e-24: 101: 38.73		CBLB_HUMAN (47-509): 0: 780: 49.79
+	Hs
		337348 ABL1_HUMAN (4-140): 3.2e-24: 102: 38.73		CBL_HUMAN (48-518): 0: 776: 47.69
+	Hs
		69201 A9UF07_HUMAN (4-140): 6.95e-24: 101: 38.73		CBL_HUMAN (48-518): 0: 776: 47.69
+	Hs
		610281 ABL2_HUMAN (4-140): 1.56e-23: 100: 37.32		CBL_HUMAN (48-518): 0: 776: 47.69
+	Mm
		610555 CSK_MOUSE (2-138): 2.38e-19: 87.4: 32.43		CBL_MOUSE (48-518): 0: 782: 47.69
+	Hs
		1357075 CD2AP_HUMAN (1-221): 1.54e-33: 128: 17.20		CBLC_HUMAN (48-451): 0: 642: 42.96