HitPredict

Interactor 1: KDM5A (P29375)
Lysine-specific demethylase 5A (EC 1.14.11.67) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) ([histone H3]-trimethyl-L-lysine(4) demethylase 5A)
Gene: KDM5A

Interactor 2: H31 (P68431)
Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)
Gene: H3C1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	36089195, 35866897
Identification Methods	proximity labelling technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1690 Hs			1 136
+	Hs
		666535 KDM5A_HUMAN (1-1690): 0: 1849: 100.00		H31T_HUMAN (1-136): 1.27e-61: 187: 97.06
+	Hs
		666523 KDM5A_HUMAN (1-1690): 0: 1849: 100.00		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		666539 KDM5A_HUMAN (1-1690): 0: 1849: 100.00		H32_HUMAN (1-136): 6.5e-61: 185: 99.27
+	Hs
		1086304 KDM5D_HUMAN (8-1602): 0: 1482: 47.25		H31T_HUMAN (1-136): 1.27e-61: 187: 97.06
+	Dm
		356114 KDM5_DROME (13-1668): 0: 1479: 39.47		H3_DROME (1-136): 6.5e-61: 185: 99.27
+	Hs
		782353 KDM5C_HUMAN (8-1593): 0: 1427: 48.81		H32_HUMAN (1-136): 6.5e-61: 185: 99.27
+	Sp
		457185 LID2_SCHPO (30-1368): 0: 877: 20.10		H31_SCHPO (1-136): 3.54e-59: 181: 91.91
+	Sp
		498409 LID2_SCHPO (30-1368): 0: 877: 20.10		H33_SCHPO (1-136): 7.45e-58: 177: 91.18
+	Sc
		902025 ECM5_YEAST (14-1309): 0: 759: 15.76		H3_YEAST (1-136): 1.16e-55: 172: 88.97
+	Sc
		812506 JHD2_YEAST (16-705): 3.56e-155: 494: 26.09		H3_YEAST (1-136): 1.16e-55: 172: 88.97
+	Hs
		183098 KDM6A_HUMAN (329-736): 6.2e-89: 321: 17.82		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		183122 KDM6A_HUMAN (329-736): 6.2e-89: 321: 17.82		H31T_HUMAN (1-136): 1.27e-61: 187: 97.06
+	Hs
		183127 KDM6A_HUMAN (329-736): 6.2e-89: 321: 17.82		H32_HUMAN (1-136): 6.5e-61: 185: 99.27
+	Hs
		935339 KDM5B_HUMAN (856-1664): 3.65e-85: 311: 19.17		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		301134 KDM4B_HUMAN (330-663): 7.98e-85: 305: 24.79		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		301136 KDM4B_HUMAN (330-663): 7.98e-85: 305: 24.79		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		935232 KDM4C_HUMAN (330-655): 7.67e-82: 295: 24.50		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		301146 KDM4B_HUMAN (330-663): 7.98e-85: 305: 24.79		H3C_HUMAN (1-136): 5.49e-58: 177: 93.38
+	Hs
		952622 KDM4C_HUMAN (330-655): 7.67e-82: 295: 24.50		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		1174653 KDM4C_HUMAN (330-655): 7.67e-82: 295: 24.50		H32_HUMAN (1-136): 6.5e-61: 185: 99.27