HitPredict

Interactor 1: LTK (P29376)
Leukocyte tyrosine kinase receptor (EC 2.7.10.1) (Protein tyrosine kinase 1)
Gene: LTK

Interactor 2: DSC2 (Q02487)
Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III)
Gene: DSC2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 864 Hs			1 901
+	Hs
		872427 EPHA5_HUMAN (389-809): 8.73e-124: 400: 26.02		DSC2_HUMAN (1-901): 0: 855: 100.00
+	Hs
		435643 IGF1R_HUMAN (298-854): 3.35e-128: 419: 27.39		DSC3_HUMAN (1-901): 0: 806: 66.70
+	Hs
		411386 INSR_HUMAN (367-837): 3.2e-121: 400: 30.82		DSC3_HUMAN (1-901): 0: 806: 66.70
+	Hs
		508000 FGFR1_HUMAN (333-827): 2.64e-122: 390: 24.42		DSC3_HUMAN (1-901): 0: 806: 66.70
+	Hs
		537741 INSRR_HUMAN (391-827): 1.68e-110: 369: 34.69		DSC3_HUMAN (1-901): 0: 806: 66.70
+	Hs
		507817 FGFR1_HUMAN (333-827): 2.64e-122: 390: 24.42		CADH1_HUMAN (28-897): 0: 714: 28.09
+	Hs
		521744 EPHA2_HUMAN (446-813): 2.21e-109: 360: 30.38		CADH1_HUMAN (28-897): 0: 714: 28.09
+	Hs
		435534 IGF1R_HUMAN (298-854): 3.35e-128: 419: 27.39		CADH3_HUMAN (7-897): 0: 635: 27.50
+	Hs
		666595 LTK_HUMAN (1-864): 0: 763: 100.00		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18
+	Hs
		434321 RET_HUMAN (278-849): 5.71e-146: 461: 25.98		PCDGH_HUMAN (1-464): 7.02e-94: 318: 16.74
+	Hs
		434134 RET_HUMAN (278-849): 5.71e-146: 461: 25.98		CADH2_HUMAN (4-385): 1.04e-51: 197: 15.55
+	Hs
		600717 EPHA1_HUMAN (25-817): 9.44e-137: 433: 19.11		PCDA8_HUMAN (358-864): 2.34e-50: 193: 13.02
+	Hs
		435531 IGF1R_HUMAN (298-854): 3.35e-128: 419: 27.39		CADH2_HUMAN (4-385): 1.04e-51: 197: 15.55
+	Hs
		507842 FGFR1_HUMAN (333-827): 2.64e-122: 390: 24.42		CADH2_HUMAN (4-385): 1.04e-51: 197: 15.55
+	Hs
		508295 FGFR1_HUMAN (333-827): 2.64e-122: 390: 24.42		PCDA8_HUMAN (358-864): 2.34e-50: 193: 13.02
+	Hs
		507929 FGFR1_HUMAN (333-827): 2.64e-122: 390: 24.42		CAD11_HUMAN (4-349): 8.21e-46: 178: 18.78
+	Hs
		601509 FGFR2_HUMAN (163-833): 6.48e-137: 429: 20.03		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18
+	Hs
		665396 EPHA3_HUMAN (388-798): 3.64e-124: 400: 27.30		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18
+	Hs
		872440 EPHA5_HUMAN (389-809): 8.73e-124: 400: 26.02		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18
+	Hs
		507992 FGFR1_HUMAN (333-827): 2.64e-122: 390: 24.42		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18