HitPredict

Interactor 1: CASP1 (P29452)
Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
Gene: CASP1

Interactor 2: NLRC4 (Q3UP24)
NLR family CARD domain-containing protein 4 (Caspase recruitment domain-containing protein 12) (Ice protease-activating factor) (Ipaf)
Gene: NLRC4

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.777

Property	Details
Experiments	22885697, 26449474
Identification Methods	anti tag coimmunoprecipitation, fluorescence polarization spectroscopy
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	CARD~CARD
Common GO terms	GO:0005829 - cytosol GO:0006915 - apoptotic process GO:0032731 - positive regulation of interleukin-1 beta production GO:0042742 - defense response to bacterium GO:0070269 - pyroptotic inflammatory response and 1 others more... GO:0072557 - IPAF inflammasome complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 402 Mm			1 1024
+	Hs
		667491 CASP1_HUMAN (1-402): 2.06e-160: 458: 61.63		NLRC4_HUMAN (1-1024): 0: 705: 75.00
+	Hs
		876977 CASP9_HUMAN (1-398): 5.95e-119: 353: 24.11		BIRC1_HUMAN (96-1015): 7.68e-138: 451: 21.88
+	Hs
		667478 CASP1_HUMAN (1-402): 2.06e-160: 458: 61.63		NAL10_HUMAN (26-583): 4.46e-95: 317: 13.51
+	Mm
		667128 CASP1_MOUSE (1-402): 7.01e-164: 467: 100.00		NLRP3_MOUSE (826-1023): 3.92e-26: 118: 24.12
+	Hs
		667484 CASP1_HUMAN (1-402): 2.06e-160: 458: 61.63		NLRP3_HUMAN (805-1023): 1.43e-23: 109: 21.82
+	Hs
		667480 CASP1_HUMAN (1-402): 2.06e-160: 458: 61.63		NALP7_HUMAN (734-1020): 2.25e-20: 99.4: 13.85
+	Hs
		667501 CASP1_HUMAN (1-402): 2.06e-160: 458: 61.63		NOD1_HUMAN (847-1024): 7.46e-20: 97.8: 18.54
+	Mm
		667127 CASP1_MOUSE (1-402): 7.01e-164: 467: 100.00		NOD2_MOUSE (794-1024): 5.82e-17: 88.6: 17.87
+	Hs
		667493 CASP1_HUMAN (1-402): 2.06e-160: 458: 61.63		NALP2_HUMAN (778-1023): 9.64e-20: 97.5: 18.62
+	Hs
		667490 CASP1_HUMAN (1-402): 2.06e-160: 458: 61.63		NOD2_HUMAN (796-1024): 2.91e-19: 95.9: 17.60
+	Hs
		667487 CASP1_HUMAN (1-402): 2.06e-160: 458: 61.63		NLRP1_HUMAN (859-1020): 2.19e-15: 83.6: 20.25
+	Hs
		667448 CASP1_HUMAN (1-402): 2.06e-160: 458: 61.63		NLRP6_HUMAN (761-906): 7.02e-10: 65.5: 18.37
+	Hs
		830305 CASP4_HUMAN (1-402): 1.43e-141: 409: 44.91		NOD1_HUMAN (847-1024): 7.46e-20: 97.8: 18.54
+	Hs
		830296 CASP4_HUMAN (1-402): 1.43e-141: 409: 44.91		NOD2_HUMAN (796-1024): 2.91e-19: 95.9: 17.60
+	Hs
		851077 CASP5_HUMAN (3-402): 2.8e-134: 393: 43.14		NLRP1_HUMAN (859-1020): 2.19e-15: 83.6: 20.25
+	Hs
		877005 CASP9_HUMAN (1-398): 5.95e-119: 353: 24.11		NOD1_HUMAN (847-1024): 7.46e-20: 97.8: 18.54
+	Hs
		788267 CASP2_HUMAN (5-402): 1.36e-113: 341: 24.19		NOD1_HUMAN (847-1024): 7.46e-20: 97.8: 18.54
+	Hs
		877001 CASP9_HUMAN (1-398): 5.95e-119: 353: 24.11		NLRP1_HUMAN (859-1020): 2.19e-15: 83.6: 20.25
+	Hs
		788263 CASP2_HUMAN (5-402): 1.36e-113: 341: 24.19		NLRP1_HUMAN (859-1020): 2.19e-15: 83.6: 20.25
+	Hs
		1166744 CASPC_HUMAN (106-402): 2.34e-108: 323: 44.33		NOD2_HUMAN (796-1024): 2.91e-19: 95.9: 17.60