Interactor 1: IL12B (P29460)
Interleukin-12 subunit beta (IL-12B) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) (IL-12 subunit p40) (NK cell stimulatory factor chain 2) (NKSF2)
Gene: IL12B

Interactor 2: IL12B (P29460)
Interleukin-12 subunit beta (IL-12B) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) (IL-12 subunit p40) (NK cell stimulatory factor chain 2) (NKSF2)
Gene: IL12B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.55 1.00 0.747

The method score is based on:

Property Details
Experiments 7527811
Identification Methods comigration in non denaturing gel electrophoresis, affinity chromatography technology, chromatography technology
Interaction Type physical association, disulfide bond

The annotation score is based on:

Property Details
Interacting Pfam domains IL12p40_C~IL12p40_C
Common GO terms GO:0001817 - regulation of cytokine production
GO:0001916 - positive regulation of T cell mediated cytotoxicity
GO:0002230 - positive regulation of defense response to virus by host
GO:0002323 - natural killer cell activation involved in immune response
GO:0002827 - positive regulation of T-helper 1 type immune response
and 64 others

more...

Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 328
Hs

1 328
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Last updated: 15 Jul 2024