Interactor 1: IL12B (P29460)
Interleukin-12 subunit beta (IL-12B) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) (IL-12 subunit p40) (NK cell stimulatory factor chain 2) (NKSF2)
Gene: IL12B

Interactor 2: IL23A (Q9NPF7)
Interleukin-23 subunit alpha (IL-23 subunit alpha) (IL-23-A) (Interleukin-23 subunit p19) (IL-23p19)
Gene: IL23A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.88 1.00 0.939

The method score is based on:

Property Details
Experiments 29997244, 11114383, 18708069, 18680750, 12023369
Identification Methods affinity chromatography technology, fluorescent resonance energy transfer, anti tag coimmunoprecipitation, x-ray crystallography, anti bait coimmunoprecipitation, luminescence based mammalian interactome mapping
Interaction Type physical association, direct interaction, disulfide bond, association

The annotation score is based on:

Property Details
Interacting Pfam domains IL12p40_C~IL23
Common GO terms GO:0001916 - positive regulation of T cell mediated cytotoxicity
GO:0002230 - positive regulation of defense response to virus by host
GO:0002827 - positive regulation of T-helper 1 type immune response
GO:0005125 - cytokine activity
GO:0005576 - extracellular region
and 28 others

more...

Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 328
Hs

1 189
+ Mm
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024