Interactor 1: CASP1 (P29466)
Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
Gene: CASP1

Interactor 2: CASP1 (P29466)
Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
Gene: CASP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.82 1.00 0.910

The method score is based on:

Property Details
Experiments 11432859, 14634131, 8700869, 27043298, 24630722
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, protease assay, 3D electron microscopy, fluorescence polarization spectroscopy
Interaction Type physical association, protein cleavage, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains CARD~CARD, Peptidase_C14~Peptidase_C14
Common GO terms GO:0002221 - pattern recognition receptor signaling pathway
GO:0004175 - endopeptidase activity
GO:0004197 - cysteine-type endopeptidase activity
GO:0005730 - nucleolus
GO:0005737 - cytoplasm
and 38 others

more...

Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 404
Hs

1 404
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Last updated: 15 Jul 2024