HitPredict

Interactor 1: CASP1 (P29466)
Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
Gene: CASP1

Interactor 2: PA24A (P47712)
Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)]
Gene: PLA2G4A

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	9875225
Identification Methods	protease assay
Interaction Type	cleavage reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 404 Hs			1 749
+	Hs
		788161 CASP3_HUMAN (119-401): 3.4e-96: 290: 25.00		PA24A_HUMAN (1-749): 0: 911: 100.00
+	Hs
		812813 CASP7_HUMAN (102-400): 4.41e-95: 288: 20.19		PA24A_HUMAN (1-749): 0: 911: 100.00
+	Hs
		812823 CASP8_HUMAN (111-399): 5.86e-84: 266: 20.33		PA24A_HUMAN (1-749): 0: 911: 100.00
+	Hs
		473772 CASP1_HUMAN (1-404): 0: 514: 100.00		PA24B_HUMAN (10-139): 4.7e-23: 106: 26.72
+	Hs
		473774 CASP3_HUMAN (119-401): 3.4e-96: 290: 25.00		PA24B_HUMAN (10-139): 4.7e-23: 106: 26.72
+	Hs
		473775 CASP7_HUMAN (102-400): 4.41e-95: 288: 20.19		PA24B_HUMAN (10-139): 4.7e-23: 106: 26.72
+	Hs
		473779 CASP8_HUMAN (111-399): 5.86e-84: 266: 20.33		PA24B_HUMAN (10-139): 4.7e-23: 106: 26.72