HitPredict

Interactor 1: CASP1 (P29466)
Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
Gene: CASP1

Interactor 2: CAR16 (Q5EG05)
Caspase recruitment domain-containing protein 16 (Caspase recruitment domain-only protein 1) (CARD-only protein 1) (Caspase-1 inhibitor COP) (Pseudo interleukin-1 beta converting enzyme) (Pseudo-ICE) (Pseudo-IL1B-converting enzyme)
Gene: CARD16

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.62 1.00 0.789

The method score is based on:

Property Details
Experiments 11432859, 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains CARD~CARD
Common GO terms GO:0019900 - kinase binding
GO:0032991 - protein-containing complex
GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
GO:0050700 - CARD domain binding
GO:0050727 - regulation of inflammatory response
and 6 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 404
Hs

1 197
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024